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Synonyms: unsym-Trichlorobenzene; 1,2,4-Trichlorobenzol
OSHA IMIS Code Number: 2481
Chemical Abstracts Service (CAS) Registry Number: 120-82-1
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DC2100000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2321 153 (liquid)
NIOSH Pocket Guide to Chemical Hazards, 1,2,4-Trichlorobenzene: chemical description, physical properties, potentially hazardous incompatibilities, and more
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 37 mg/m3 Ceiling
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 40 mg/m3 Ceiling
Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity
Potential Symptoms: Irritation of eyes, skin, mucous membrane; in animals: liver, kidney damage; possible teratogenic effects; INGES. ACUTE: Abdominal pain, vomiting.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Liver damage (HE4)
Affected Organs: Eyes, skin, respiratory system, liver, reproductive system
- OSHA does not have a PEL for 1,2,4-trichlorobenzene.
- EPA's oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of 1,2,4-trichlorobenzene is 0.01 mg/kg/day.
- Rat liver microsomes metabolize 1,2,4-trichlorobenzene predominantly to 2,3,6-trichlorophenol and 2,4,5-trichlorophenol. Relatively small amounts of other trichlorophenol isomers are also produced. Covalent binding to microsomal protein during this metabolism is thought to be due to the formation of reactive quinone metabolites.
- NIOSH Pocket Guide to Chemical Hazards: 1,2,4-Trichlorobenzene.
- International Chemical Safety Cards (WHO/IPCS/ILO): 1,2,4-Trichlorobenzene.
- US EPA Integrated Risk Information System: 1,2,4-Trichlorobenzene (CASRN 120-82-1).
- den Besten, C., Smink, M.C., de Vries, E.J. and van Bladeren, P.J.: Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites. Toxicol. Appl. Pharmacol. 108(2): 223-233, 1991.
- den Besten, C., et al.: The liver, kidney, and thyroid toxicity of chlorinated benzenes. Toxicol. Appl. Pharmacol. 111(1): 69-81, 1991.
- Pohanish, R.P. (editor): 1,2,4-Trichlorobenzene. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2242-2244.
Date Last Revised: 04/02/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Teflon Filter (Type LS) followed by an Amberlite XAD-2 Tube (100/50 mg sections, 20/50 mesh)
analytical solvent: Hexane
minimum time: 15 Minutes
maximum time: 60 Minutes
maximum flow rate: 0.2 L/min (Ceiling)
current analytical method: Gas Chromatography; GC/ECD
method reference: (NIOSH 5517 [24 KB PDF, 5 pages])
method classification: Fully Validated
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