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Chemical Sampling Information (CSI)
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General Description

Synonyms: unsym-Trichlorobenzene; 1,2,4-Trichlorobenzol

OSHA IMIS Code Number: 2481

Chemical Abstracts Service (CAS) Registry Number: 120-82-1

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DC2100000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2321 153 (liquid)

NIOSH Pocket Guide to Chemical Hazards, 1,2,4-Trichlorobenzene: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 37 mg/m3 Ceiling

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 40 mg/m3 Ceiling

Health Factors

Carcinogenic Classification:

Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity

Potential Symptoms: Irritation of eyes, skin, mucous membrane; in animals: liver, kidney damage; possible teratogenic effects; INGES. ACUTE: Abdominal pain, vomiting.

Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Liver damage (HE4)

Affected Organs: Eyes, skin, respiratory system, liver, reproductive system

Notes:

  1. OSHA does not have a PEL for 1,2,4-trichlorobenzene.
  2. EPA's oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of 1,2,4-trichlorobenzene is 0.01 mg/kg/day.
  3. Rat liver microsomes metabolize 1,2,4-trichlorobenzene predominantly to 2,3,6-trichlorophenol and 2,4,5-trichlorophenol. Relatively small amounts of other trichlorophenol isomers are also produced. Covalent binding to microsomal protein during this metabolism is thought to be due to the formation of reactive quinone metabolites.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: 1,2,4-Trichlorobenzene.
  • International Chemical Safety Cards (WHO/IPCS/ILO): 1,2,4-Trichlorobenzene.
  • US EPA Integrated Risk Information System: 1,2,4-Trichlorobenzene (CASRN 120-82-1).
  • den Besten, C., Smink, M.C., de Vries, E.J. and van Bladeren, P.J.: Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites. Toxicol. Appl. Pharmacol. 108(2): 223-233, 1991.
  • den Besten, C., et al.: The liver, kidney, and thyroid toxicity of chlorinated benzenes. Toxicol. Appl. Pharmacol. 111(1): 69-81, 1991.
  • Pohanish, R.P. (editor): 1,2,4-Trichlorobenzene. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2242-2244.

Date Last Revised: 04/02/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Teflon Filter (Type LS) followed by an Amberlite XAD-2 Tube (100/50 mg sections, 20/50 mesh)
    analytical solvent: Hexane
    minimum time: 15 Minutes
    maximum time: 60 Minutes
    maximum flow rate: 0.2 L/min (Ceiling)
    current analytical method: Gas Chromatography; GC/ECD
    method reference: (NIOSH 5517 [24 KB PDF, 5 pages])
    method classification: Fully Validated

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