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Toluene-2,6-diisocyanate

General Description

  • Synonyms: 2,6-Toluene diisocyanate; 2,6-TDI; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene
  • OSHA IMIS Code Number: T177
  • Chemical Abstracts Service (CAS) Registry Number: 91-08-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CZ6310000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2078 156
  • IPCS International Chemical Safety Card - Toluene-2,6-diisocyanate: Acute hazards, symptoms, physical and chemical dangers, physical properties, and more

Exposure Limits and Health Effects

Exposure Limit Limit Values HE Codes Health Factors and Target Organs
OSHA Permissible Exposure Limit (PEL) Not established    
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL) Not established    
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2004)*

0.005 ppm
(0.036 mg/m3)
TWA

0.02 ppm
(0.14 mg/m3)
STEL

SEN; A4

HE9 Respiratory sensitization, asthma
HE11 Bronchitis, pneumonitis, pulmonary edema
HE14 Eye, mucous membrane, and respiratory irritation
CAL/OSHA PEL Not established    

* In the ACGIH 2012 Notice of Intended Changes, ACGIH proposed the following limit values and notations: 0.001 ppm TWA (inhalable fraction); 0.003 ppm STEL (inhalable fraction); Skin; SEN; A3; basis: asthma.

  • Carcinogenic Classification:
    • National Toxicology Program (NTP) carcinogenic classification: Reasonably anticipated to be a human carcinogen (PDF)
    • National Toxicology Program (NTP) carcinogenic classification: Group 2B (possibly carcinogenic to humans [toluene diisocyanates])
    • U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed
    • EPA Inhalation Reference Concentration (RfC): Not established
    • Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established
  • NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: Not listed
  • Notes on Other Potential Health Effects and Hazards:
    1. Toluene-2,6-diisocyanate is combustible and can release irritating or toxic fumes/gases in a fire (NIOSH/IPCS 1998).
    2. Death from severe asthma in sensitized workers has been reported (NIOSH 1996).
    3. Studies of chronic effects in animals show that cancer is associated with exposure to commercial-grade toluene diisocyanate (TDI) (an 80:20 mixture of 2,4- and 2,6-TDI) (NIOSH 1989).
    4. Once sensitized, workers may continue to exhibit the health effects of TDI several years after exposure has ended (ACGIH 2004).
    5. Individuals sensitized to TDI may develop a chronic-like syndrome that includes coughing, wheezing, tightness or congestion in the chest, and shortness of breath (ACGIH 2004).
  • Literature Basis:
  • Date Last Revised: 9/6/2012

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Coated Glass Fiber Filter (37 mm open face) Coated with 1.0 mg 1-(2-Pyridyl)piperazine
  • maximum volume: 240 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU
  • method reference: OSHA Manual of Analytical Methods (OSHA 42)
  • method classification: Fully Validated
  • note: OSHA personnel may obtain filters from SLTC and refrigerate until used.
On-Site Sampling Techniques/Methods:
  • Detector Tube
  • manufacturer: Dräger
  • model/type: Toluene Diisocyanate 0.02/a, order no. 67 24501
  • sampling information: 25 strokes
  • upper measurement limit: 0.2 ppm
  • detection limit: approx. 0.02 ppm
  • standard deviation: ±30%
  • method reference: on-site air secondary (manufacturer)

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