- Synonyms: 2,6-Toluene diisocyanate; 2,6-TDI; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene
- OSHA IMIS Code Number: T177
- Chemical Abstracts Service (CAS) Registry Number: 91-08-7
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CZ6310000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2078 156
- IPCS International Chemical Safety Card - Toluene-2,6-diisocyanate: Acute hazards, symptoms, physical and chemical dangers, physical properties, and more
Exposure Limits and Health Effects
|Exposure Limit||Limit Values||HE Codes||Health Factors and Target Organs|
|OSHA Permissible Exposure Limit (PEL)||Not established|
|National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)||Not established|
|American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2004)*||
|HE9||Respiratory sensitization, asthma|
|HE11||Bronchitis, pneumonitis, pulmonary edema|
|HE14||Eye, mucous membrane, and respiratory irritation|
|CAL/OSHA PEL||Not established|
* In the ACGIH 2012 Notice of Intended Changes, ACGIH proposed the following limit values and notations: 0.001 ppm TWA (inhalable fraction); 0.003 ppm STEL (inhalable fraction); Skin; SEN; A3; basis: asthma.
- Carcinogenic Classification:
- National Toxicology Program (NTP) carcinogenic classification: Reasonably anticipated to be a human carcinogen (PDF)
- National Toxicology Program (NTP) carcinogenic classification: Group 2B (possibly carcinogenic to humans [toluene diisocyanates])
- U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed
- EPA Inhalation Reference Concentration (RfC): Not established
- Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established
- NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: Not listed
- Notes on Other Potential Health Effects and Hazards:
- Toluene-2,6-diisocyanate is combustible and can release irritating or toxic fumes/gases in a fire (NIOSH/IPCS 1998).
- Death from severe asthma in sensitized workers has been reported (NIOSH 1996).
- Studies of chronic effects in animals show that cancer is associated with exposure to commercial-grade toluene diisocyanate (TDI) (an 80:20 mixture of 2,4- and 2,6-TDI) (NIOSH 1989).
- Once sensitized, workers may continue to exhibit the health effects of TDI several years after exposure has ended (ACGIH 2004).
- Individuals sensitized to TDI may develop a chronic-like syndrome that includes coughing, wheezing, tightness or congestion in the chest, and shortness of breath (ACGIH 2004).
- Literature Basis:
- ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) -Toluene-2,4 or 2,6-Diisocyanate (or as a mixture). 2004.
- NIOSH: Alert -Preventing asthma and death from diisocyanate exposure. DHHS (NIOSH) Publication No. 96-111. 1996.
- NIOSH: Current Intelligence Bulletin 53 - Toluene Diisocyanate (TDI) and Toluenediamine (TDA) -Evidence of Carcinogenicity. December 1989.
- NIOSH/ICPS: International Chemical Safety Cards - Toluene-2,6-diisocyanate. November 1998.
- Date Last Revised: 9/6/2012
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Coated Glass Fiber Filter (37 mm open face) Coated with 1.0 mg 1-(2-Pyridyl)piperazine
- maximum volume: 240 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU
- method reference: OSHA Manual of Analytical Methods (OSHA 42)
- method classification: Fully Validated
- note: OSHA personnel may obtain filters from SLTC and refrigerate until used.
On-Site Sampling Techniques/Methods:
- Detector Tube
- manufacturer: Dräger
- model/type: Toluene Diisocyanate 0.02/a, order no. 67 24501
- sampling information: 25 strokes
- upper measurement limit: 0.2 ppm
- detection limit: approx. 0.02 ppm
- standard deviation: ±30%
- method reference: on-site air secondary (manufacturer)
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