- Chemical Sampling Information
Synonyms: 2,6-Toluene diisocyanate; 2,6-TDI; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene
OSHA IMIS code: T177
CAS number(s): 91-08-7
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
- coated glass fiber filter (37 mm open face) coated with 1.0 mg 1-(2-Pyridyl)piperazine
- maximum volume: 240 L
- maximum flow rate: 1.0 L/min
- current analytical method: high performance liquid chromatography; HPLC/UV/FLU
- method reference: OSHA 42 (fully validated)
- note: OSHA personnel may obtain filters from the OSHA-Salt Lake Technical Center (SLTC) and refrigerate until used.
On-Site Sampling Techniques/Methods:
- Detector Tube
- manufacturer: Dräger
- model/type: Toluene Diisocyanate 0.02/a, order no. 67 24501
- sampling information: 25 strokes
- upper measurement limit: 0.2 ppm
- detection limit: approx. 0.02 ppm
- standard deviation: ±30%
- method reference: on-site air secondary (manufacturer)
Exposure Limits and Health Effects (Updated September 6, 2012)
|Standard Set By||Exposure Limit||Health Effect Codes -- Health Effects and Target Organs|
|OSHA PEL||Not established|
|NIOSH REL||Not established|
|ACGIH TLV® (2015)||0.001 ppm (0.007 mg/m3) (inhalable fraction and vapor) TWA
0.005 ppm (0.035 mg/m3) (inhalable fraction and vapor) STEL
Skin; dermal sensitizer (DSEN); respiratory sensitizer (RSEN)
|HE9 -- respiratory sensitization, asthma|
|HE11 -- Bronchitis, pneumonitis, pulmonary edema|
|HE14 -- eye, mucous membrane, and respiratory irritation|
|CAL/OSHA PELs||Not established|
- NTP: Reasonably anticipated to be a human carcinogen
- IARC: Group 2B (possibly carcinogenic to humans [toluene diisocyanates])
- EPA: Not listed
EPA Inhalation Reference Concentration (RfC): Not established
ATSDR Inhalation Minimal Risk Levels (MRLs): Not established
NIOSH IDLH concentration: Not established
Notes on other potential health effects and hazards:
- Toluene-2,6-diisocyanate is combustible and can release irritating or toxic fumes/gases in a fire (NIOSH/IPCS 1998).
- Death from severe asthma in sensitized workers has been reported (NIOSH 1996).
- Studies of chronic effects in animals show that cancer is associated with exposure to commercial-grade toluene diisocyanate (TDI) (an 80:20 mixture of 2,4- and 2,6-TDI) (NIOSH 1989).
- Once sensitized, workers may continue to exhibit the health effects of TDI several years after exposure has ended (ACGIH 2004).
- Individuals sensitized to TDI may develop a chronic-like syndrome that includes coughing, wheezing, tightness or congestion in the chest, and shortness of breath (ACGIH 2004).
Partial reference list:
- ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Toluene-2,4 or 2,6-Diisocyanate (or as a mixture). 2016.
- NIOSH: Alert -Preventing asthma and death from diisocyanate exposure. DHHS (NIOSH) Publication No. 96-111. 1996.
- NIOSH: Current Intelligence Bulletin 53 - Toluene Diisocyanate (TDI) and Toluenediamine (TDA) -Evidence of Carcinogenicity. December 1989.
- NIOSH/CEC/ICPS: International Chemical Safety Cards - Toluene-2,6-diisocyanate. November 1998.
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