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Toluene-2,6-diisocyanate

General Description

Synonyms: 2,6-Toluene diisocyanate; 2,6-TDI; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene

OSHA IMIS code: T177

CAS number(s): 91-08-7

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL Not established
 
NIOSH REL Not established  
ACGIH TLV® (2015) 0.001 ppm (0.007 mg/m3) (inhalable fraction and vapor) TWA
0.005 ppm (0.035 mg/m3) (inhalable fraction and vapor) STEL
Skin; dermal sensitizer (DSEN); respiratory sensitizer (RSEN)
A3
HE9 -- respiratory sensitization, asthma
HE11 -- Bronchitis, pneumonitis, pulmonary edema
HE14 -- eye, mucous membrane, and respiratory irritation
CAL/OSHA PELs Not established
 

Carcinogenic classification:

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: Not established

Notes on other potential health effects and hazards:

  1. Toluene-2,6-diisocyanate is combustible and can release irritating or toxic fumes/gases in a fire (NIOSH/IPCS 1998).
  2. Death from severe asthma in sensitized workers has been reported (NIOSH 1996).
  3. Studies of chronic effects in animals show that cancer is associated with exposure to commercial-grade toluene diisocyanate (TDI) (an 80:20 mixture of 2,4- and 2,6-TDI) (NIOSH 1989).
  4. Once sensitized, workers may continue to exhibit the health effects of TDI several years after exposure has ended (ACGIH 2004).
  5. Individuals sensitized to TDI may develop a chronic-like syndrome that includes coughing, wheezing, tightness or congestion in the chest, and shortness of breath (ACGIH 2004).

Partial reference list:

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