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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2,4,6-Trinitrophenylmethylnitramine; N-Methyl-N-2,4,6-tetranitroaniline; Nitramine; Tetralite; 2,4,6-Tetryl; 2,4,6-Trinitrophenyl-N-methylnitramine

OSHA IMIS Code Number: 2410

Chemical Abstracts Service (CAS) Registry Number: 479-45-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BY6300000

NIOSH Pocket Guide to Chemical Hazards, Tetryl: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 - 1.5 mg/m3 TWA; Skin

Construction Industry: 29 CFR 1926.55 Appendix A - 1.5 mg/m3 TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 1.5 mg/m3 TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1.5 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1.5 mg/m3 TWA; Skin

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 750 mg/m3

Potential Symptoms: Sensitization dermatitis, itching, erythema; edema on nasal folds, cheeks, neck; keratitis (inflammation of the cornea), conjunctivitis; nosebleeds; sneezing; anemia; cough, coryza, wheezing; irritability, malaise, headache, lassitude, insomnia; nausea, vomiting, abdominal pain; yellow stains of skin and hair; hair loss; liver, kidney damage

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild to Marked (HE14-16); Asthma-like symptoms (HE9); Allergic contact dermatitis/Cumulative systemic toxicity (HE3); Mutagen (HE2); CNS effects (HE7); Explosive (HE18)

Affected Organs: Eyes, skin, respiratory system, CNS, liver, kidneys, GI tract

Notes:

  1. The extent of tetryl absorption through the skin, the metabolism of tetryl in humans, the mechanism of tetryl toxicity, and specific biomarkers for medical surveillance have not been elucidated.
  2. Because the CNS effects are minor and nonspecific, it is possible that most of them may occur secondarily to intense itching from dermatitis, intestinal discomfort, or respiratory symptoms that interfere with sleep.
  3. The anemia is generally mild and there is no conclusive evidence to associate it with exposure to tetryl.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Tetryl.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Tetryl.
  • No authors: Toxicological Profile for Tetryl. Agency for Toxic Substances and Disease Registry. U.S. Department of Health and Human Services, 1995, 113 pages.
  • Pohanish, R.P. (editor): Tetryl. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2189-2190.

Date Last Revised: 04/12/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns
    maximum volume: 100 Liters
    maximum flow rate: 1.5 L/min
    current analytical method: Colorimetric
    method reference: NIOSH Analytical Method (NIOSH S225)
    method classification: Fully Validated

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