Synonyms: 2,4,6-Trinitrophenylmethylnitramine; N-Methyl-N-2,4,6-tetranitroaniline; Nitramine; Tetralite; 2,4,6-Tetryl; 2,4,6-Trinitrophenyl-N-methylnitramine
OSHA IMIS Code Number: 2410
Chemical Abstracts Service (CAS) Registry Number: 479-45-8
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BY6300000
NIOSH Pocket Guide to Chemical Hazards, Tetryl: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Table Z-1 - 1.5 mg/m3 TWA; Skin
Construction Industry: 29 CFR 1926.55 Appendix A - 1.5 mg/m3 TWA; Skin
Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 1.5 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1.5 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1.5 mg/m3 TWA; Skin
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 750 mg/m3
Potential Symptoms: Sensitization dermatitis, itching, erythema; edema on nasal folds, cheeks, neck; keratitis (inflammation of the cornea), conjunctivitis; nosebleeds; sneezing; anemia; cough, coryza, wheezing; irritability, malaise, headache, lassitude, insomnia; nausea, vomiting, abdominal pain; yellow stains of skin and hair; hair loss; liver, kidney damage
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild to Marked (HE14-16); Asthma-like symptoms (HE9); Allergic contact dermatitis/Cumulative systemic toxicity (HE3); Mutagen (HE2); CNS effects (HE7); Explosive (HE18)
Affected Organs: Eyes, skin, respiratory system, CNS, liver, kidneys, GI tract
- The extent of tetryl absorption through the skin, the metabolism of tetryl in humans, the mechanism of tetryl toxicity, and specific biomarkers for medical surveillance have not been elucidated.
- Because the CNS effects are minor and nonspecific, it is possible that most of them may occur secondarily to intense itching from dermatitis, intestinal discomfort, or respiratory symptoms that interfere with sleep.
- The anemia is generally mild and there is no conclusive evidence to associate it with exposure to tetryl.
- NIOSH Pocket Guide to Chemical Hazards: Tetryl.
- International Chemical Safety Cards (WHO/IPCS/ILO): Tetryl.
- No authors: Toxicological Profile for Tetryl. Agency for Toxic Substances and Disease Registry. U.S. Department of Health and Human Services, 1995, 113 pages.
- Pohanish, R.P. (editor): Tetryl. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2189-2190.
Date Last Revised: 04/12/2006
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns
maximum volume: 100 Liters
maximum flow rate: 1.5 L/min
current analytical method: Colorimetric
method reference: NIOSH Analytical Method (NIOSH S225)
method classification: Fully Validated
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