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Chemical Sampling Information (CSI)
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General Description

Synonyms: TML; Lead tetramethyl; Motor fuel anti-knock compound; Lead, organic

OSHA IMIS Code Number: 2370

Chemical Abstracts Service (CAS) Registry Number: 75-74-1

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TP4725000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1649 56

NIOSH Pocket Guide to Chemical Hazards, Tetramethyl Lead (as Pb): chemical description, physical properties, potentially hazardous incompatibilities, and more

Chemical Description and Physical Properties:
colorless liquid or dyed red, orange, or blue with a slight musty odor
molecular weight: 267
boiling point: 230°F
vapor pressure: 22 mm
melting point: -22°F
Incompatibilities: Strong oxidizers, such as sulfuryl chloride or potassium permanganate

Exposure Limits

OSHA Permissible Exposure Limit (PEL):
General Industry: 0.075 mg/m3 (Skin)

Construction Industry: 0.15 mg/m3 TWA (Skin)
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.15 mg/m3 TWA (Skin)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.075 mg/m3 TWA (Skin)


Health Factors

Carcinogenic Classification:
International Agency for Research on Cancer (IARC): Group 3, not classifiable as to its carcinogenicity to humans (Lead and Lead Compounds, Organolead)
Potential Symptoms: Insomnia, bad dreams, restlessness, anxiety; hypotension; nausea, anorexia; delirium, mania; convulsions; coma

Health Effects: Cumulative liver and kidney damage (HE3) Cumulative CNS damage (HE7); Acute CNS effects (HE4)

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • sampling media: Glass Fiber Filter in series with a Charcoal Tube (100/50 mg sections, 20/40 mesh)
    maximum volume: 480 Liters
    minimum volume: 240 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Atomic Absorption Spectroscopy; AAS
    method reference: 2 (OSHA In-House File)
    method classification: Partially Validated
    note: Submit as a separate sample. When analysis of a compound is requested, an elemental analysis (from charcoal tube)is performed and reported as lead.
  • sampling media: Glass Fiber Filter (37 mm) in series with an XAD-2 Tube (100/50 mg sections, 20/50 mesh)
    maximum volume: 200 Liters
    minimum volume: 30 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/PID
    method reference: 1 (NIOSH 2534 [19 KB PDF, 4 pages])
    method classification: Partially Validated

Wipe Sampling Method:

  • sampling media: Whatman Smear Tab filter
    analytical solvent: Distilled Water (See note - reported as total lead)
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