Synonyms: Sulfur difluoride dioxide; Vikane®
OSHA IMIS Code Number: 2323
Chemical Abstracts Service (CAS) Registry Number: 2699-79-8
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WT5075000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2191 123
NIOSH Pocket Guide to Chemical Hazards, Sulfuryl Fluoride: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Table Z-1 - 5 ppm, 20 mg/m3 TWA
Construction Industry: 29 CFR 1926.55 Appendix A - 5 ppm, 20 mg/m3 TWA
Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 5 ppm, 20 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 21 mg/m3 TWA; 10 ppm, 42 mg/m3 STEL
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 20 mg/m3 TWA; 10 ppm, 40 mg/m3 STEL
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm
Potential Symptoms: Conjunctivitis; rhinitis; pharyngitis; cough, dyspnea, pulmonary edema (may be delayed); nausea, vomiting; weakness; tremor, convulsions; paresthesia; decreased sense of smell; frostbite (from liquid)
Health Effects: Acute lung damage---pulmonary edema (HE11); Acute CNS effects (HE4)
Affected Organs: Eyes, skin, respiratory system, CNS, kidneys
- No pharmacokinetic studies were found in the literature, but individuals exposed to high levels of sulfuryl fluoride had elevated serum fluoride concentrations.
- Repeated exposure of rats and rabbits (100-600 ppm) resulted in dose-related renal toxicity only in rats, and no evidence for kidney toxicity has been reported in fumigation workers.
- NIOSH Pocket Guide to Chemical Hazards: Sulfuryl Fluoride.
- International Chemical Safety Cards (WHO/IPCS/ILO): Sulfuryl fluoride.
- Calvert, G.M., et al.: Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers. Am. J. Public Health 88(12): 1774-1780, 1998.
- Eisenbrandt, D.L. and Nitschke, K.D.: Inhalation toxicity of sulfuryl fluoride in rats and rabbits. Fundam. Appl. Toxicol. 12(3): 540-557, 1989.
- Nuckolls, J.G., et al.: Fatalities resulting from sulfuryl fluoride: exposure after home fumigation - Virginia. MMWR Morb. Mortal. Wkly. Rep. 36(36): 602-604, 1987.
- Pohanish, R.P. (editor): Sulfuryl Fluoride. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2130-2132.
Date Last Revised: 08/11/2004
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Charcoal tube (800/200 mg sections, 20/40 mesh)
maximum volume: 10 Liters
maximum flow rate: 0.1 L/min
current analytical method: Ion Chromatography; IC/Conductivity
method reference: NIOSH Analytical Method (NIOSH 6012 [25 KB PDF, 4 pages])
method classification: Fully Validated
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