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Chemical Sampling Information (CSI)
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General Description

Synonyms: Nux vomica, Strynchnos

OSHA IMIS Code Number: 2275

Chemical Abstracts Service (CAS) Registry Number: 57-24-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WL2275000; 79005

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN1692 151 Poison

NIOSH Pocket Guide to Chemical Hazards, Strychnine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Chemical Description and Physical Properties:

colorless, odorless solid
molecular weight: 334
vapor pressure: approx. 0 mm
boiling point: Decomposes
melting point: 547°F

Incompatibilities: Strong oxidizers

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 0.15 mg/m3

Construction Industry: 0.15 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.15 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.15 mg/m3 TWA

Health Factors

Potential Symptoms: Stiff neck, facial muscles; restlessness, apprehension, increased acuity of perception; increased reflex excitability; cyanosis; tetanic convulsions with opisthotonos

Health Effects: Acute systemic toxicity, CNS (Convulsion and Paralysis) (HE4)

Affected Organs: CNS

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Glass Fiber Filter (37 mm)
    maximum volume: 1000 Liters
    maximum flow rate: 3.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: 1 (NIOSH 5016)
    method classification: Fully Validated

Conditions: Column: C18; Mobile Phase: 50:50 Acetonitrile: Water; Detector Wavelength: 254 nm

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