<< Back to Chemical Sampling Information

Chemical Sampling Information (CSI)
Search (use word(s)/phrase)
Table of Contents
By Name
A B C D E F G H I J K L M
N O P Q R S T U V W X Y Z

By CAS Number
Quick Links

General Description

Synonyms: 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-[1]benzopyrano [3,4-b]furo[2,3-h][1] benzopyran-6(6aH)-one; Tubatoxin; Cube; Derris, Prentox; Nicouline

OSHA IMIS Code Number: 2228

Chemical Abstracts Service (CAS) Registry Number: 83-79-4

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DJ2800000

NIOSH Pocket Guide to Chemical Hazards, Rotenone: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen; (TLV listed under Rotenone (Commercial))

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2,500 mg/m3

Potential Symptoms: Irritation of eyes, skin, respiratory system; numbness of mucous membrane; nausea, vomiting, abdominal pain; muscle tremors, incoordination, clonic convulsions; stupor; hypoglycemia; headache; confusion; cough; labored breathing; pulmonary edema (may be delayed); eye damage (upon direct eye contact); severe rash (with repeated skin contact); INGES ACUTE: Abdominal cramps, vomiting, diarrhea; convulsions.

Health Effects: Cumulative systemic toxicity (HE3); Irritation-Eye, Nose, Throat, Skin---Mild (HE16) Suspect dopaminergic neurotoxin---parkinsonism (HE7)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes: Rotenone has been used to produce an animal model of Parkinson's disease due to its ability to cause specific dopaminergic neurotoxicity after parenteral administration. It remains to be determined whether occupational exposure to rotenone increases the risk of parkinsonism.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Rotenone.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Rotenone.
  • Gao, H.M., Hong, J.S., Zhang, W. and Liu, B.: Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J. Neurosci. 23(4): 1228-1236, 2003.
  • Pohanish, R.P. (editor): Rotenone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2007-2009.
  • Sherer, T.B., et al.: Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23(34): 10756-10764, 2003.

Date Last Revised: 07/13/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Polytetrafluorethylene (FA) filter, 1.0 micron
    maximum volume: 400 Liters
    maximum flow rate: 3.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: (NIOSH 5007 [19 KB PDF, 3 pages])
    method classification: Fully Validated

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.

** All Trademarks are the property of their respective owners.


Accessibility Assistance: Contact the OSHA Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.