Synonyms: 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-benzopyrano [3,4-b]furo[2,3-h] benzopyran-6(6aH)-one; Tubatoxin; Cube; Derris, Prentox; Nicouline
OSHA IMIS Code Number: 2228
Chemical Abstracts Service (CAS) Registry Number: 83-79-4
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DJ2800000
NIOSH Pocket Guide to Chemical Hazards, Rotenone: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 TWA
Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 TWA
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen; (TLV listed under Rotenone (Commercial))
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2,500 mg/m3
Potential Symptoms: Irritation of eyes, skin, respiratory system; numbness of mucous membrane; nausea, vomiting, abdominal pain; muscle tremors, incoordination, clonic convulsions; stupor; hypoglycemia; headache; confusion; cough; labored breathing; pulmonary edema (may be delayed); eye damage (upon direct eye contact); severe rash (with repeated skin contact); INGES ACUTE: Abdominal cramps, vomiting, diarrhea; convulsions.
Health Effects: Cumulative systemic toxicity (HE3); Irritation-Eye, Nose, Throat, Skin---Mild (HE16) Suspect dopaminergic neurotoxin---parkinsonism (HE7)
Affected Organs: Eyes, skin, respiratory system, CNS
Notes: Rotenone has been used to produce an animal model of Parkinson's disease due to its ability to cause specific dopaminergic neurotoxicity after parenteral administration. It remains to be determined whether occupational exposure to rotenone increases the risk of parkinsonism.
- NIOSH Pocket Guide to Chemical Hazards: Rotenone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Rotenone.
- Gao, H.M., Hong, J.S., Zhang, W. and Liu, B.: Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J. Neurosci. 23(4): 1228-1236, 2003.
- Pohanish, R.P. (editor): Rotenone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2007-2009.
- Sherer, T.B., et al.: Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23(34): 10756-10764, 2003.
Date Last Revised: 07/13/2004
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Polytetrafluorethylene (FA) filter, 1.0 micron
maximum volume: 400 Liters
maximum flow rate: 3.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: (NIOSH 5007 [19 KB PDF, 3 pages])
method classification: Fully Validated
- Limit the amount of bulk submitted to one gram or one mL.
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