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Chemical Sampling Information (CSI)
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General Description

Synonyms: 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-
(4-methyl-1-piperazinyl)formimidoyl]-2,7-[epoxypentadeca(1,11,13)trienimino]-
naphtho(2,1-b)furan-1,11(2H)-dione-21-acetate; 3-(4-methylpiperazinyliminomethyl) rifamycin SV; NSC113926; Rifampin

OSHA IMIS Code Number: R300

Chemical Abstracts Service (CAS) Registry Number: 13292-46-1

Chemical Description and Physical Properties:

orange to brown powder
molecular weight: 823.0
molecular formula: C43H58N4O12
melting point: 183-188°C

Health Factors

Potential Symptoms: irritant to skin, eyes, mucous membranes, and respiratory system; may cause nausea, vomiting, excessive tiredness, abnormal liver functioning resulting in yellowing of the eyes

Health Effects: irritant to skin, eyes, mucous membranes, and respiratory system

Affected Organs: skin, eyes, respiratory system, mucous membranes

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: 37 mm Glass Fiber Filter
    analytical solvent: Acetonitrile
    maximum volume: 480 liters
    maximum flow rate: 2 L/min (TWA)
    current analytical method: High Performance Liquid Chromatography; HPLC/U
    method reference: 2 (OSHA In-House File)
    method classification: Partially Validated

Conditions: Column: C18; Mobile Phase: 30:70 acetonitrile: 0.025 M (NH4)H2PO4 at 1.5 ml/min; Detector Wavelength: 238nm

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