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Chemical Sampling Information (CSI)
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General Description

Synonyms: EGPE; Ethylene glycol monopropyl ether; Propyl Cellosolve; Propylglycol

OSHA IMIS Code Number: P136

Chemical Abstracts Service (CAS) Registry Number: 2807-30-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KM2800000

Chemical Description and Physical Properties:

clear colorless flammable liquid; soluble in water and most solvents; mild reasonably pleasant odor
molecular weight: 104.149
vapor pressure: 130 Pa @ 25°C
molecular formula: C5H12O2
boiling point: 149.5-150.5°C
melting point: -90°C

Health Factors

Potential Symptoms: Eye, nose, throat and skin irritation; cough, sore throat; eye redness, pain; dry skin.

Health Effects: Irritation-Eyes---Marked (HE14); Irritation-Nose, Throat, Skin---Mild (HE16); Blood disorders (HE12)

Affected Organs: Eyes, skin, respiratory system, blood

Notes:

  1. Explosive vapor/air mixtures may be formed with 2-propoxyethanol at temperatures above 57°C.
  2. No reports of adverse effects on humans were found in the literature. Oral and inhalational studies in rats indicated red blood cells as the primary site of action (hematuria), with secondary changes occurring in spleen, liver and kidneys. The overall NOEL of 2-propoxyethanol in inhalational studies was reported to be 200 ppm.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Ethylene glycol monopropyl ether.
  • Katz, G.V., Krasavage, W.J. and Terhaar, C.J.: Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. Environ. Health Perspect. 57: 165-175, 1984.

Date Last Revised: 09/20/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride: Methanol
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA (In-House File)
    method classification: Not Validated

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