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Chemical Sampling Information (CSI)
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General Description

Synonyms: Benzenethiol; Mercaptobenzene; Thiophenol

OSHA IMIS Code Number: P105

Chemical Abstracts Service (CAS) Registry Number: 108-98-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DC0525000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2337 131

NIOSH Pocket Guide to Chemical Hazards, Benzenethiol: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 0.45 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 ppm, 0.5 mg/m3 (15 Minutes) Ceiling (REL listed under Benzenethiol)

Health Factors

Potential Symptoms: Irritation of eyes, skin, respiratory system; dermatitis; cyanosis; sore throat; cough, wheezing, dyspnea (breathing difficulty), pulmonary edema, pneumonitis; headache, dizziness, CNS depression; eye redness, pain, blurred vision; nausea, vomiting; kidney, liver, spleen damage

Health Effects: Irritation Eye, Nose, Throat---Marked (HE14); Offensive Odor (HE20)

Affected Organs: Eyes, skin, respiratory system, CNS, kidneys, liver, spleen

Notes:

  1. OSHA does not have a PEL for phenyl mercaptan.
  2. Phenyl mercaptan is listed by the FDA as a synthetic flavoring substance that is permitted for direct addition to food for human consumption (21 CFR 172.515).
  3. The inhalational LC50s in rats and mice were reported to be 33 ppm and 28 ppm, respectively, with most of the deaths at concentrations comparable to the LC50s occurring 2-15 days following a single 4-hour exposure to phenyl mercaptan.
  4. The NOAELs for developmental toxicity during gestation were 20 mg/kg/day and ≥40 mg/kg/day in rats and rabbits, respectively, when phenyl mercaptan was administered by oral gavage in corn oil. Phenyl mercaptan also had reproductive toxicity in rats with an indeterminate NOAEL, as the lowest-dose group (9 mg/kg/day) had increased liver and kidney weights, as well as microscopic changes in these organs.

Literature Basis:

Date Last Revised: 03/16/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated Glass Fiber Filter (37mm Gelman Type A) Coating is 5% (w/v) mercuric acetate solution
    analytical solvent: 25% Hydrochloric acid
    maximum volume: 20 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2075)
    method classification: Partially Validated
    note: Protect samples from light until analysis.

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