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Chemical Sampling Information (CSI)
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General Description

Synonyms: Methyl propyl ketone; Ethyl acetone; MPK

OSHA IMIS Code Number: 2010

Chemical Abstracts Service (CAS) Registry Number: 107-87-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: SA7875000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1249 127

NIOSH Pocket Guide to Chemical Hazards, 2-Pentanone: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 200 ppm, 700 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 200 ppm, 700 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 200 ppm, 700 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 200 ppm, 705 mg/m3 TWA; 250 ppm, 881 mg/m3 STEL (TLV listed under Methyl propyl ketone)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 150 ppm, 530 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,500 ppm

Potential Symptoms: Irritation of eyes, skin, mucous membrane; cough, sore throat; headache; dry, cracked skin, dermatitis; dizziness, drowsiness, narcosis, coma; INGES. ACUTE: Abdominal pain, nausea

Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. Vapor/air mixtures may be explosive.
  2. Listed among FDAs "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515).
  3. 2-Pentanone was identified among the VOCs found in the breath of rats, and its concentration was increased by an inhibitor of cytochrome P450 2E1.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: 2-Pentanone.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Methyl propyl ketone.
  • Mathews, J.M., Raymer, J.H., Etheridge, A.S., Velez, G.R. and Bucher, J.R.: Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo? Toxicol. Appl. Pharmacol. 146(2): 255-260, 1997.
  • Pohanish, R.P. (editor): 2-Pentanone. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1808-1810.

Date Last Revised: 05/22/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min (TWA)
    maximum volume: 3 Liters
    maximum flow rate: 0.2 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: (NIOSH 1300 [26 KB PDF, 5 pages])
    method classification: Fully Validated

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