Oxalic acid is a normal minor metabolite of carbohydrates (e.g., fructose), glycine, and vitamin C, but it is produced in toxic amounts after ethylene glycol intoxication.
Kidney dialysis patients may be particularly susceptible to oxalate-induced nephrotoxicity and neurotoxicity.
Prolonged barbiturate sleeping time in rats treated with star fruit juice was attributed to its high oxalate content, indicating a possible inhibition of some drug-metabolizing cytochrome P-450s in the liver.
Calcium oxalate crystals, which occur in certain plants, may cause irritant contact dermatitis in agricultural workers.
International Chemical Safety Cards (WHO/IPCS/ILO): Oxalic acid.
Chen, C.L., Chou, K.J., Wang, J.S., Yeh, J.H., Fang, H.C. and Chung, H.M.: Neurotoxic effects of carambola in rats: the role of oxalate. J. Formos. Med. Assoc. 101 (5): 337-441, 2002.
Pohanish, R.P. (editor): Oxalic Acid. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1763-1765.
Rofe, A.M., James, H.M., Bais, R., Edwards, J.B. and Conyers, R.A.: The production of (14C) oxalate during the metabolism of (14C) carbohydrates in isolated rat hepatocytes. Aust. J. Exp. Biol. Med. Sci. 58 (2): 103-116, 1980.
Salinas, M.L., Ogura, T. and Soffchi, L.: Irritant contact dermatitis caused by needle-like calcium oxalate crystals, raphides, in Agave tequilana among workers in tequila distilleries and agave plantations. Contact Dermatitis44(2): 94-96, 2001.
Tse, K.C., et al.: Star fruit intoxication in uraemic patients: case series and review of the literature. Intern. Med. J. 33 (7): 314-316, 2003.
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