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N-Nitrosopyrrolidine

General Description

  • Synonyms: NO-Pyr; NPYR; 1-Nitroso-pyrrolidine; N-N-Pyr
  • OSHA IMIS Code Number: 1950
  • Chemical Abstracts Service (CAS) Registry Number: 930-55-2
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UY1575000
  • Chemical Description and Physical Properties:
    • yellow liquid
    • molecular formula: C4H8N2O
    • molecular weight: 100.2
    • flash point: 82°C
    • boiling point: 214°C/760 mm Hg

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Irritation of eyes, skin
  • Health Effects: Suspected carcinogen (HE2)
  • Affected Organs: Liver (rats), lungs (mice)
  • Notes:
    1. N-Nitrosopyrrolidine is an OSHA Select Carcinogen without a PEL.
    2. N-Nitrosopyrrolidine undergoes activation by α-hydroxylation via the cytochrome P450 2A family (e.g., CYP2A6) to metabolites that form adducts with guanine in RNA and DNA.
    3. Production of upper respiratory tumors (laryngeal or tracheal) was observed with a single i.p. injection of N-nitrosopyrrolidine in Syrian golden hamsters.
    4. N-Nitrosopyrrolidine has been found in some sun-dried foods and nitrite-preserved foods (e.g., bacon), as well as in cigarette smoke.
  • Literature Basis:
    • U.S. EPA Integrated Risk Information System: N-Nitrosopyrrolidine (CASRN 930-55-2).
    • Hunt, E.J. and Shank, R.C.: Formation and persistence of a DNA adduct in rodents treated with N-nitrosopyrrolidine. Carcinogenesis 12(4): 571-575, 1991.
    • McCoy, G.D., DeMarco, G.J., Haxhiu, L., Roggero, E., Sudilovsky, E.C. and Sudilovsky, O.: Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters. Cancer Lett. 79(2): 161-165, 1994.
    • No Author: N-Nitrosopyrrolidine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
    • Pohanish, R.P. (editor): N-Nitrosopyrrolidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1743-1744.
    • Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, 1991.
    • Wong, M. and Hecht, S.S.: A cyclic N7,C8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chem. Res. Toxicol. 10(7): 772-778, 1997.
    • Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, 2005.
  • Date Last Revised: 08/11/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • ThermoSorb/N Tube
  • maximum volume: 75 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/TEA
  • analytical solvent: (75:25) Dichloromethane:Methanol
  • method reference: OSHA Analytical Method (OSHA 27)
  • method classification: Fully Validated
  • note: OSHA personnel may obtain ThermoSorb/N Tube from the Salt Lake Technical Center (SLTC). Store samples in freezer.
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

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