Powered by GoogleTranslate


General Description

  • Synonyms: NPIP; NO-Pip; 1-Nitrosopiperidine
  • OSHA IMIS Code Number: 1949
  • Chemical Abstracts Service (CAS) Registry Number: 100-75-4
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TN2100000
  • Chemical Description and Physical Properties:
    • yellow liquid
    • molecular formula: C5H10N2O
    • molecular weight: 114.15
    • boiling point: 217°C/721 mm Hg

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Irritation of eyes, inflammation of pigmented area, clouded patches of vision from corneal damage; liver damage
  • Health Effects: Suspected carcinogen (HE2); Possible permanent damage to eyes (HE14)
  • Affected Organs: Eyes; in rats: esophagus, liver, nasal cavity, stomach
  • Notes:
    1. N-Nitrosopiperidine is an OSHA Select Carcinogen without a PEL, and it appears to be used only as a research chemical.
    2. It is thought to undergo activation by α-hydroxylation via the cytochrome P450 2A family (e.g., CYP2A6) to metabolites that form adducts with guanine in DNA, which may be involved in carcinogenesis.
    3. N-Nitrosopiperidine has been found in some sun-dried foods, smoked fish, meats (e.g., bacon) and other foods preserved with sodium nitrite.
    4. N-Nitrosopiperidine was detected in urine from 52/59 non-smokers who were tested, and it appeared to be associated with the consumption of coffee, according to one report.
  • Literature Basis:
    • No Author: Nitrosamines, 15 Listings (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
    • Levallois, P., et al.: Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem. Toxicol. 38(11): 1013-1019, (2000).
    • Pohanish, R.P. (editor): N-Nitrosopiperidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, (2002), pp. 1741-1742.
    • Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, (1991).
    • Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, (2005).
  • Date Last Revised: 08/16/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • ThermoSorb/N Tube
  • maximum volume: 75 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/TEA
  • analytical solvent: (75:25) Dichloromethane:Methanol
  • method reference: OSHA Analytical Method (OSHA 27)
  • method classification: Fully Validated
  • note: OSHA personnel may obtain ThermoSorb/N Tube from the Salt Lake Technical Center (SLTC). Store samples in freezer.
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

** All Trademarks are the property of their respective owners.

*Accessibility Assistance: Contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.

All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.

**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.

Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.