Potential Symptoms: Irritation of eyes, skin; in animals: liver damage; [potential occupational carcinogen]
Health Effects: Animal carcinogen (liver, lung, esophagus, nasal/paranasal) (HE2).
Affected Organs: Liver
N-Nitrosodipropylamine is an OSHA Select Carcinogen. OSHA does not have a PEL for this chemical.
Absorption of N-nitrosodipropylamine through human skin has been demonstrated.
N-Nitrosodipropylamine undergoes activation by cytochrome P450 2E1 to metabolites that result in the chemical modification of DNA (N7 alkylation of guanine nucleotides). Other potential metabolites include propionaldehyde, propylamine, nitric oxide and nitrite.
The co-administration of ethanol, a known inducer of hepatic CYP2E1, was reported to enhance the carcinogenicity of chronic oral N-nitrosodipropylamine in mice.
In 2005, the California Department of Health Services established a notification level for N-nitrosodipropylamine of 10 nanograms per liter of drinking water after finding it (and N-nitrosodimethylamine) in some resins being evaluated for drinking water treatment.
No Author: N-Nitrosodi-n-Propylamine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Pohanish, R.P. (editor): N-Nitrosodipropylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1736-1738.
Teiber, J.F. and Hollenberg, P.F.: Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. Carcinogenesis21(8): 1559-1566, 2000.
Teiber, J.F., Macé, K. and Hollenberg, P.F.: Metabolism of the β-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-β-hydroxypropylpropylamine and N-nitroso-β-oxypropylpropylamine. Carcinogenesis22(3): 499-506, 2001.
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.
U.S. Department of Labor | Occupational Safety & Health Administration | 200 Constitution Ave., NW, Washington, DC 20210 Telephone: 800-321-OSHA (6742) | TTY www.OSHA.gov
Thank You for Visiting Our Website
You are exiting the Department of Labor's Web server.
The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.