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N-Nitrosodipropylamine

General Description

  • Synonyms: NDPA; Di-n-propylnitrosamine; N-Nitrosodi-n-propylamine; DPNA; DPN; N-Nitroso-N-propyl-1-propanamine; propylamine, N-Nitroso-N-di; Dipropylnitrosamine; N-Propyl-N-nitrosopropylamine
  • OSHA IMIS Code Number: 1948
  • Chemical Abstracts Service (CAS) Registry Number: 621-64-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JL9700000
  • Chemical Description and Physical Properties:
    • liquid
    • molecular formula: C6H14N2O
    • molecular weight: 130.2
    • boiling point: 194.5°C
    • vapor pressure: 997.582 mmHg @ 31.1111°C
    • flash point: 98.89°C

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Irritation of eyes, skin; in animals: liver damage; [potential occupational carcinogen]
  • Health Effects: Animal carcinogen (liver, lung, esophagus, nasal/paranasal) (HE2).
  • Affected Organs: Liver
  • Notes:
    1. N-Nitrosodipropylamine is an OSHA Select Carcinogen. OSHA does not have a PEL for this chemical.
    2. Absorption of N-nitrosodipropylamine through human skin has been demonstrated.
    3. N-Nitrosodipropylamine undergoes activation by cytochrome P450 2E1 to metabolites that result in the chemical modification of DNA (N7 alkylation of guanine nucleotides). Other potential metabolites include propionaldehyde, propylamine, nitric oxide and nitrite.
    4. The co-administration of ethanol, a known inducer of hepatic CYP2E1, was reported to enhance the carcinogenicity of chronic oral N-nitrosodipropylamine in mice.
    5. In 2005, the California Department of Health Services established a notification level for N-nitrosodipropylamine of 10 nanograms per liter of drinking water after finding it (and N-nitrosodimethylamine) in some resins being evaluated for drinking water treatment.
  • Literature Basis:
    • U.S. EPA Integrated Risk Information System: N-Nitrosodi-N-propylamine (CASRN 621-64-7).
    • Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodi-n-propylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
    • California Department of Health Services: California drinking water; activities related to NDMA and other nitrosamines, 2005.
    • No Author: N-Nitrosodi-n-Propylamine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
    • Pohanish, R.P. (editor): N-Nitrosodipropylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1736-1738.
    • Teiber, J.F. and Hollenberg, P.F.: Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. Carcinogenesis 21(8): 1559-1566, 2000.
    • Teiber, J.F., Macé, K. and Hollenberg, P.F.: Metabolism of the β-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-β-hydroxypropylpropylamine and N-nitroso-β-oxypropylpropylamine. Carcinogenesis 22(3): 499-506, 2001.
  • Date Last Revised: 11/14/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • ThermoSorb/N Tube
  • maximum volume: 75 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/TEA
  • analytical solvent: 75/25 (v/v) Dichloromethane/Methanol
  • method reference: OSHA Analytical Method (OSHA 27)
  • method classification: Fully Validated
  • note: OSHA personnel may obtain ThermoSorb/N Tube from the Salt Lake Technical Center (SLTC). Store samples in freezer.
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

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