Synonyms: NDPA; Diphenyl nitrosamine; Redax; Vulcatard; NDFA
OSHA IMIS Code Number: N109
Chemical Abstracts Service (CAS) Registry Number: 86-30-6
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JJ9800000
Chemical Description and Physical Properties:
molecular weight: 198.24
molecular formula: C12H10N2O
boiling point: 101 °C
melting point: 66.5°C
Incompatibilities: Reacts vigorously with oxidants
Environmental Protection Agency (EPA): Group B2, Probable human carcinogen
International Agency for Research on Cancer (IARC): Group 3, Not classifiable as to its carcinogenicity to humans
Potential Symptoms: Unknown in humans
Health Effects: Unknown in humans; animal carcinogen (bladder cancer) (HE2)
Affected Organs: Urinary bladder (in rodents)
- OSHA does not have a PEL for N-nitrosodiphenylamine.
- Major metabolites in urine include 4-hydroxydiphenylamine and 4,4'-dihydroxydiphenylamine, indicating a denitrosation to diphenylamine and nitric oxide, with subsequent hydroxylation of the diphenylamine. Nitrate and nitrite are further metabolites (of nitric oxide) that have been identified in rat urine.
- International Chemical Safety Cards (WHO/IPCS/ILO): N-Nitrosodiphenylamine.
- U.S. EPA Integrated Risk Information System: N-Nitrosodiphenylamine (CASRN 86-30-6).
- McGregor, D.: The genetic toxicology of N-nitrosodiphenylamine. Mutation Res. 317(3): 195-211, 1994.
- Pohanish, R.P. (editor): N-Nitrosodiphenylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1733-1735.
Date Last Revised: 11/23/2005
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Midget Fritted Glass Bubbler (MFGB) containing 15 mL Isopropanol
maximum volume: 250 Liters
maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA 23)
method classification: Fully Validated
note: The samples must be protected from light during and after sampling. Wrap Bubbler with black tape to protect from light. Samples must be either stored in a freezer and shipped frozen or analyzed within six days after collection.
Conditions: Column: CN; Mobile Phase: 60:40 Methanol:Water; Detector Wavelength: 280nm; Detection Limit: 3.5 ug/m3
- Limit the amount of bulk submitted to one gram or one mL.