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Chemical Sampling Information (CSI)
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General Description

Synonyms: NDPA; Diphenyl nitrosamine; Redax; Vulcatard; NDFA

OSHA IMIS Code Number: N109

Chemical Abstracts Service (CAS) Registry Number: 86-30-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JJ9800000

Chemical Description and Physical Properties:

yellow flakes
molecular weight: 198.24
molecular formula: C12H10N2O
boiling point: 101 °C
melting point: 66.5°C

Incompatibilities: Reacts vigorously with oxidants

Health Factors

Carcinogenic Classification:

Environmental Protection Agency (EPA): Group B2, Probable human carcinogen

International Agency for Research on Cancer (IARC): Group 3, Not classifiable as to its carcinogenicity to humans

Potential Symptoms: Unknown in humans

Health Effects: Unknown in humans; animal carcinogen (bladder cancer) (HE2)

Affected Organs: Urinary bladder (in rodents)

Notes:

  1. OSHA does not have a PEL for N-nitrosodiphenylamine.
  2. Major metabolites in urine include 4-hydroxydiphenylamine and 4,4'-dihydroxydiphenylamine, indicating a denitrosation to diphenylamine and nitric oxide, with subsequent hydroxylation of the diphenylamine. Nitrate and nitrite are further metabolites (of nitric oxide) that have been identified in rat urine.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): N-Nitrosodiphenylamine.
  • U.S. EPA Integrated Risk Information System: N-Nitrosodiphenylamine (CASRN 86-30-6).
  • McGregor, D.: The genetic toxicology of N-nitrosodiphenylamine. Mutation Res. 317(3): 195-211, 1994.
  • Pohanish, R.P. (editor): N-Nitrosodiphenylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1733-1735.

Date Last Revised: 11/23/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Midget Fritted Glass Bubbler (MFGB) containing 15 mL Isopropanol
    maximum volume: 250 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA 23)
    method classification: Fully Validated
    note: The samples must be protected from light during and after sampling. Wrap Bubbler with black tape to protect from light. Samples must be either stored in a freezer and shipped frozen or analyzed within six days after collection.

Conditions: Column: CN; Mobile Phase: 60:40 Methanol:Water; Detector Wavelength: 280nm; Detection Limit: 3.5 ug/m3

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.