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General Description

  • Synonyms: NDELA; DELNA; 2,2'-Iminodi-N-nitrosoethanol; bis(beta-Hydroxyethyl)nitrosamine; Nitrosoiminodiethanol; 2,2'-(Nitrosoimino) bis[ethanol]; N-Nitrosobis(2-hydroxyethyl)amine; NCI-C55583; Diethylamine, 2,2'-Dihydroxy-N-nitroso; Diethanolnitrosamine
  • OSHA IMIS Code Number: 0907
  • Chemical Abstracts Service (CAS) Registry Number: 1116-54-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9550000
  • Chemical Description and Physical Properties:
    • yellow, viscous oil
    • molecular formula: C4H10N2O3
    • molecular weight: 134.1
    • boiling point: 114°C

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Irritation of eyes, skin, respiratory tract; liver damage; [potential occupational carcinogen]
  • Health Effects: Known animal and suspected human carcinogen (liver, esophagus, lung) (HE2); Suspect teratogen (HE5)
  • Affected Organs: Liver, esophagus, stomach (in animals)
  • Notes:
    1. N-Nitrosodiethanolamine (NDELA) is an OSHA Select Carcinogen without a PEL.
    2. A study of the urinary excretion of NDELA by workers exposed to metal-working fluids (MWF) reported post-shift concentrations about 100-fold greater in urine from those working with nitrite-formulated MWF than from those working with "nitrite-fee" MWF.
    3. Metal workers exposed to ~1 µg/m3 NDELA were reported to have about double the DNA single strand breaks in their white blood cells as those exposed to <0.05 µg/m3.
    4. The genotoxicity of NDELA may involve the production of active metabolites that react with DNA to form glyoxaldeoxyguanosine and O(6)-2-hydroxyethylguanosine DNA adducts, as demonstrated in the livers of rats.
  • Literature Basis:
    • U.S. EPA Integrated Risk Information System: N-Nitrosodiethanolamine (CASRN 1116-54-7).
    • Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health 76(8): 591-597, 2003.
    • Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
    • Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
    • No Author: N-Nitrosodiethanolamine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

Date Last Revised: 05/23/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Glass Fiber Filter (Gelman Type A open face), no backup pad
  • maximum volume: 480 Liters
  • maximum flow rate: 2.0 L/min
  • current analytical method: Gas Chromatography; GC/TEA
  • analytical solvent: Isopropanol
  • alternate analytical method: High Performance Liquid Chromatography; HPLC/UV
  • method reference: OSHA Analytical Method (OSHA 31)
  • method classification: Fully Validated
  • note: Air sample and bulk must be protected from light. Collect a sample of the bulk substance and send to the lab in a separate mailing container at the time the air samples are submitted. Indicate on the sample sheet that a bulk sample has been submitted.

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