Health Effects: Known animal and suspected human carcinogen (liver, esophagus, lung) (HE2); Suspect teratogen (HE5)
Affected Organs: Liver, esophagus, stomach (in animals)
N-Nitrosodiethanolamine (NDELA) is an OSHA Select Carcinogen without a PEL.
A study of the urinary excretion of NDELA by workers exposed to metal-working fluids (MWF) reported post-shift concentrations about 100-fold greater in urine from those working with nitrite-formulated MWF than from those working with "nitrite-fee" MWF.
Metal workers exposed to ~1 µg/m3 NDELA were reported to have about double the DNA single strand breaks in their white blood cells as those exposed to <0.05 µg/m3.
The genotoxicity of NDELA may involve the production of active metabolites that react with DNA to form glyoxaldeoxyguanosine and O(6)-2-hydroxyethylguanosine DNA adducts, as demonstrated in the livers of rats.
Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health76(8): 591-597, 2003.
Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
No Author: N-Nitrosodiethanolamine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Date Last Revised: 05/23/2006
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
Glass Fiber Filter (Gelman Type A open face), no backup pad
analytical solvent: Isopropanol
maximum volume: 480 Liters
maximum flow rate: 2.0 L/min
current analytical method: Gas Chromatography; GC/TEA
alternate analytical method: High Performance Liquid Chromatography; HPLC/UV
note: Air sample and bulk must be protected from light. Collect a sample of the bulk substance and send to the lab in a separate mailing container at the time the air samples are submitted. Indicate on the sample sheet that a bulk sample has been submitted.
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