Health Effects: Known animal and suspected human carcinogen (liver, esophagus, lung) (HE2); Suspect teratogen (HE5)
Affected Organs: Liver, esophagus, stomach (in animals)
N-Nitrosodiethanolamine (NDELA) is an OSHA Select Carcinogen without a PEL.
A study of the urinary excretion of NDELA by workers exposed to metal-working fluids (MWF) reported post-shift concentrations about 100-fold greater in urine from those working with nitrite-formulated MWF than from those working with "nitrite-fee" MWF.
Metal workers exposed to ~1 µg/m3 NDELA were reported to have about double the DNA single strand breaks in their white blood cells as those exposed to <0.05 µg/m3.
The genotoxicity of NDELA may involve the production of active metabolites that react with DNA to form glyoxaldeoxyguanosine and O(6)-2-hydroxyethylguanosine DNA adducts, as demonstrated in the livers of rats.
Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health76(8): 591-597, 2003.
Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
No Author: N-Nitrosodiethanolamine (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
note: Air sample and bulk must be protected from light. Collect a sample of the bulk substance and send to the lab in a separate mailing container at the time the air samples are submitted. Indicate on the sample sheet that a bulk sample has been submitted.
** All Trademarks are the property of their respective owners.
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.
U.S. Department of Labor | Occupational Safety & Health Administration | 200 Constitution Ave., NW, Washington, DC 20210 Telephone: 800-321-OSHA (6742) | TTY www.OSHA.gov
Thank You for Visiting Our Website
You are exiting the Department of Labor's Web server.
The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.