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Chemical Sampling Information (CSI)
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General Description

Synonyms: NDELA; DELNA; 2,2'-Iminodi-N-nitrosoethanol; bis(beta-Hydroxyethyl)nitrosamine; Nitrosoiminodiethanol; 2,2'-(Nitrosoimino) bis[ethanol]; N-Nitrosobis(2-hydroxyethyl)amine; NCI-C55583; Diethylamine, 2,2'-Dihydroxy-N-nitroso; Diethanolnitrosamine

OSHA IMIS Code Number: 0907

Chemical Abstracts Service (CAS) Registry Number: 1116-54-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9550000

Chemical Description and Physical Properties:
    yellow, viscous oil
    molecular formula: C4H10N2O3
    molecular weight: 134.1
    boiling point: 114°C
Health Factors

Carcinogenic Classification:
Environmental Protection Agency (EPA): Group B2, probable human carcinogen

International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans [104 KB PDF, 36 pages]

National Toxicology Program (NTP): Reasonably anticipated to be human carcinogen [444 KB PDF, 23 pages]
Potential Symptoms: Irritation of eyes, skin, respiratory tract; liver damage; [potential occupational carcinogen]

Health Effects: Known animal and suspected human carcinogen (liver, esophagus, lung) (HE2); Suspect teratogen (HE5)

Affected Organs: Liver, esophagus, stomach (in animals)

Notes:
  1. N-Nitrosodiethanolamine (NDELA) is an OSHA Select Carcinogen without a PEL.
  2. A study of the urinary excretion of NDELA by workers exposed to metal-working fluids (MWF) reported post-shift concentrations about 100-fold greater in urine from those working with nitrite-formulated MWF than from those working with "nitrite-fee" MWF.
  3. Metal workers exposed to ~1 µg/m3 NDELA were reported to have about double the DNA single strand breaks in their white blood cells as those exposed to <0.05 µg/m3.
  4. The genotoxicity of NDELA may involve the production of active metabolites that react with DNA to form glyoxaldeoxyguanosine and O(6)-2-hydroxyethylguanosine DNA adducts, as demonstrated in the livers of rats.
Date Last Revised: 05/23/2006

Literature Basis:
  • U.S. EPA Integrated Risk Information System: N-Nitrosodiethanolamine (CASRN 1116-54-7).
  • Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health 76(8): 591-597, 2003.
  • Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
  • Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
  • No Author: N-Nitrosodiethanolamine [444 KB PDF, 23 pages]. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Glass Fiber Filter (Gelman Type A open face), no backup pad
    analytical solvent: Isopropanol
    maximum volume: 480 Liters   
    maximum flow rate:
    2.0 L/min
    current analytical method: Gas Chromatography; GC/TEA
    alternate analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA 31)
    method classification: Fully Validated
    note: Air sample and bulk must be protected from light. Collect a sample of the bulk substance and send to the lab in a separate mailing container at the time the air samples are submitted. Indicate on the sample sheet that a bulk sample has been submitted.
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Page last updated: 04/20/2007