N-Nitrosodibutylamine is an OSHA Select Carcinogen. OSHA does not have a PEL for this chemical.
Two major metabolites of this chemical, N-nitroso-n-butyl-N-(4-hydroxybutyl)amine and N-nitroso-n-butyl-N-(3-carboxypropyl) amine also cause bladder cancer in animals.
Incubation of N-nitrosodibutylamine at a high concentration (4 mM) with human liver microsomes resulted in rates of production of the four metabolites, N-nitroso-n-butyl-N-(4-hydroxybutyl)amine N-nitroso-n-butyl-N-(3-hydroxybutyl)amine N-nitroso-n-butyl-N-(2-hydroxybutyl)amine and butyraldehyde in the approximate ratios of 1:13:4:1, respectively.
N-Nitrosodibutylamine has been found in gastric juice and may be found in some foods and rubber products exposed to nitrite during production or utilization.
No Author: N-Nitrosodi-n-Butylamine, CAS No. 924-16-3. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005.
Bellec, G., Dréano, Y., Bail, J.-P., Ménez, J.-F. and Berthou, F.: Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes. Mutat. Res. 377(2): 199-209, 1997.
Dallinga, J.W., et al.: Volatile N-nitrosamines in gastric juice of patients with various conditions of the gastrointestinal tract determined by gas chromatography-mass spectrometry and related to intragastric pH and nitrate and nitrite levels. Cancer Lett. 124(2): 119-125, 1998.
Fiddler, W., Pensabene, J., Sphon, J. and Andrzejewski. D.: Nitrosamines in rubber bands used for orthodontic purposes. Food Chem. Toxicol. 30(4): 325-326, 1992.
Heenan, M.P., Nacey, J.N., Delahunt, B., Ferguson, A.F. and Dickson, S.J.: Volatile N-nitrosamines in urinary catheters. Br. J. Urol. 63(1): 72-75, 1989.
Pohanish, R.P. (editor): N-Nitrosodi-n-Butylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1728-1730.
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