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Chemical Sampling Information (CSI)
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General Description

Synonyms: Methyl 4-hydroxybenzoate; Nipagin M; Tegosept M; Methyl Chemosept; Methyl Parasept

OSHA IMIS Code Number: M336

Chemical Abstracts Service (CAS) Registry Number: 99-76-3

Chemical Description and Physical Properties:

white needles; preservative in foods, beverages, cosmetics; freely soluble in alcohol, acetone, ether; one gram dissolves in 400 ml water
melting point: 126-128°C

Health Factors

Potential Symptoms: Itching, swelling, redness, or rash on skin; minimal to mild eye irritation.

Health Effects: Allergic contact dermatitis (uncommon); skin sensitization (rare).

Affected Organs: Skin

Notes:

  1. Readily and completely absorbed through the skin or after ingestion, hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine.
  2. May show cross-sensitivity in people allergic to local anesthetics that are metabolized to para-aminobenzoic acid.

Literature Basis:

  • Soni, M.G., Taylor, S.L., Greenberg, N.A. and Burdock, G.A.: Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem. Toxicol. 40(10): 1335-1373, 2002.

Date Last Revised: 12/11/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (Wisconsin OHL):

  • sampling media: Glass Fiber Filter (37 mm)
    current analytical method: High Performance Liquid chromatography; HPLC/UV
    method reference: Wisconsin Occupational Health Laboratory (WOHL)
    method classification: Not Validated

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