Synonyms: Methyl 4-hydroxybenzoate; Nipagin M; Tegosept M; Methyl Chemosept; Methyl Parasept
OSHA IMIS Code Number: M336
Chemical Abstracts Service (CAS) Registry Number: 99-76-3
Chemical Description and Physical Properties:
white needles; preservative in foods, beverages, cosmetics; freely soluble in alcohol, acetone, ether; one gram dissolves in 400 ml water
melting point: 126-128°C
Potential Symptoms: Itching, swelling, redness, or rash on skin; minimal to mild eye irritation.
Health Effects: Allergic contact dermatitis (uncommon); skin sensitization (rare).
Affected Organs: Skin
- Readily and completely absorbed through the skin or after ingestion, hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine.
- May show cross-sensitivity in people allergic to local anesthetics that are metabolized to para-aminobenzoic acid.
- Soni, M.G., Taylor, S.L., Greenberg, N.A. and Burdock, G.A.: Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem. Toxicol. 40(10): 1335-1373, 2002.
Date Last Revised: 12/11/2003
Primary Laboratory Sampling/Analytical Method (Wisconsin OHL):
- sampling media: Glass Fiber Filter (37 mm)
current analytical method: High Performance Liquid chromatography; HPLC/UV
method reference: Wisconsin Occupational Health Laboratory (WOHL)
method classification: Not Validated
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