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Chemical Sampling Information (CSI)
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General Description

Synonyms: Ethyl methyl ketone oxime; Ethyl methyl ketoxime; MEK oxime; 2-Butanone, oxime; USAF AM-3; USAF DO-44; USAF EK-906; Skino #2; Troykyd anti-skin B

OSHA IMIS Code Number: R250

Chemical Abstracts Service (CAS) Registry Number: 96-29-7

Chemical Description and Physical Properties:

clear, colorless to light yellow liquid; odor varies from a hardly discernible ethereal aroma to an unpleasant aromatic aroma
molecular weight: 87.13
vapor pressure: <1.07 mmHg @ 20°
molecular formula: C4H9NO
boiling point: 152°C
flash point: 59°C

Health Factors

Potential Symptoms: In animals: Irritation of mucus membranes; CNS depression; methemoglobinemia; anemia, enlarged spleen

Health Effects: No human studies were found. In animals: Anemia (HE12); Methemoglobinemia (HE13); Narcosis (HE8). Suspected animal carcinogen (HE2).

Affected Organs: Blood, liver, CNS

Notes:

  1. OSHA does not have a PEL for methyl ethyl ketoxime.
  2. Unit risk estimates of 2.53 x 10-6 per µg/m3 and 1.13 x 10-6 µg/m3 have been calculated from incidences of liver adenoma and liver carcinoma, respectively, in inhalational toxicity studies with rats.
  3. Liver tumors in rats and mice appeared late in life during chronic inhalation studies with methyl ethyl ketoxime and apparently did not shorten their lifespans.
  4. Radiolabeled methyl ethyl ketoxime was metabolized in rats to carbon dioxide, as well as to expired volatiles, a major component being methyl ethyl ketone. Urine contained 13-26% of the radiolabel.
  5. Subacute inhalational toxicology studies with mice indicated a NOEL of 3 ppm for olfactory degeneration in the nasal turbinates.

Literature Basis:

  • Burka, L.T., Black, S.R. and Mathews, J.M.: Disposition of methyl ethyl ketoxime in the rat after oral, intravenous and dermal administration. Xenobiotica 28(10): 1005-1015, 1998.
  • Newton, P.E., Bolte, H.F., Derelanko, M.J., Hardisty, J.F. and Rinehart, W.E.: An evaluation of changes and recovery in the olfactory epithelium in mice after inhalation exposure to methylethylketoxime. Inhal. Toxicol. 14(12): 1249-1260, 2002.
  • Newton, P.E., Wooding, W.L., Bolte, H.F., Derelanko, M.J., Hardisty, J.F. and Rinehart, W.E.: A chronic inhalation toxicity/oncogenicity study of methylethylketoxime in rats and mice. Inhal. Toxicol. 13(12): 1093-1116, 2001.
  • Schuhmacher-Wolz, U., Konietzka, R. and Schneider, K.: Using carcinogenic potency ranking to assign air contaminants to emission classes. Regul. Toxicol. Pharmacol. 36(3): 221-233, 2002.
  • Schulze, G.E. and Derelanko, M.J.: Assessing the neurotoxic potential of methyl ethyl ketoxime in rats. Fundam. Appl. Toxicol. 21(4): 476-485, 1993.

Date Last Revised: 09/01/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: XAD-4 (80/40 mg section)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 10 Liters  
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography : GC/FID
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Not Validated

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