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Chemical Sampling Information (CSI)
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General Description

Synonyms: MDA, DADPM; DAPM; p,p'-Methylenedianiline; Methylenedianiline; TONOX; HT972; NCI-C54604; Composite Constituent

OSHA IMIS Code Number: 1732

Chemical Abstracts Service (CAS) Registry Number: 101-77-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BY5425000; 8360

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN2651 Keep Away From Food

NIOSH Pocket Guide to Chemical Hazards, 4,4'-Methylenedianiline: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 10 ppb TWA; 100 ppb STEL; 5 ppb Action Level

Construction Industry: 29 CFR 1926.55 Appendix A -- 10 ppb TWA; 100 ppb STEL; 5 ppb Action Level

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 29 CFR 1915.1050 Methylenedianiline requirements identical to 29 CFR 1910.1050

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 0.81 mg/m3 TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Lowest Feasible Concentration (LFC), Potential Carcinogen

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans

Health Effects: Causes liver, kidney, and spleen damage in experimental animals; hepatitis in humans.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
    maximum volume: 100 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/ECD
    method reference: OSHA Manual of Analytical Methods (OSHA 57)
    method classification: Fully Validated
    note: Within ten hours after sampling, transfer filter to glass vial containing 2 mL deionized water. Filters may be obtained by OSHA personnel from the Salt Lake Technical Center.

Conditions: Column 3% OV-101; Inj 235°C; Oven 220°C; Det 335°C; Ret time 3.5 min; DL 0.008 ug/sample.

Wipe sampling:

  • sampling media: Glass Fiber Filters wetted with 0.6 mL of a 60/40 Methanol/Deionized Water solution. Wipe samples are placed in a solution of 0.07 N H2SO4 for shipment. Solutions of 60/40 Methanol/Deionized Water and 0.07 N H2SO4 are available from the Salt Lake Technical Center for OSHA staff. Kits for on-site screening of aromatic amines are available from commercial suppliers.

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