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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2-Methylcyclohexanone; alpha-Methylcyclohexanone

OSHA IMIS Code Number: 1765

Chemical Abstracts Service (CAS) Registry Number: 583-60-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GW1750000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2297 128

NIOSH Pocket Guide to Chemical Hazards, o-Methylcyclohexanone: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 460 mg/m3 TWA; Skin

Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 460 mg/m3 TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 460 mg/m3 TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 229 mg/m3 TWA; 75 ppm, 344 mg/m3 STEL; Skin

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 50 ppm, 230 mg/m3 TWA; 75 ppm, 345 mg/m3 STEL; Skin

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 600 ppm

Potential Symptoms: In animals: eye, mucous membrane irritation; narcosis; dermatitis

Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)

Affected Organs: Skin, respiratory system, liver, kidneys, CNS

Notes:

  1. o-Methylcyclohexanone is a flavoring agent (Flavor and Extract Manufacturers Association number 3946; Joint FAO/WHO Expert Committee on Food Additives number 1102) that is considered to be generally recognized as safe when used as a flavoring agent. It may also be used as a solvent in varnish and plastics manufacturing, and in rust removal.
  2. o-Methylcyclohexanone may be absorbed through the skin.
  3. No human studies on the disposition or biomonitoring of o-methylcyclohexanone were found; an efficient reduction to the corresponding alcohol by pig testicular 20-hydroxysteroid dehydrogenase has been reported.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: o-Methylcyclohexanone.
  • Nakajin, S., Tamura, F., Takase, N. and Toyoshima, S.; Carbonyl reductase activity exhibited by pig testicular 20 beta-hydroxysteroid dehydrogenase. Biol. Pharm. Bull. 29(11): 1215-1218, 1997.
  • Newberne, P., et al.: GRAS flavoring substances 19. Food Technol. 54(6): 66-68, 70, 72-74, 76-84, 2000.
  • Pohanish, R.P. (editor): 2-Methylcyclohexanone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1549-1550.

Date Last Revised: 01/05/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Porapak Q tube (150/75 mg section, 50/80 mesh)
    analytical solvent: Acetone
    maximum volume: 6 Liters   
    maximum flow rate: 0.05 L/min (TWA)
    maximum volume: 1 Liter   
    maximum flow rate: 0.1 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 2521 [24 KB PDF, 4 pages])
    method classification: Fully Validated

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