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Chemical Sampling Information (CSI)
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General Description

Synonyms: Cyclohexylmethane; Hexahydrotoluene

OSHA IMIS Code Number: 1740

Chemical Abstracts Service (CAS) Registry Number: 108-87-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GV6125000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2296 128

NIOSH Pocket Guide to Chemical Hazards, Methylcyclohexane: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 - 500 ppm, 2000 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A - 500 ppm, 2000 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 500 ppm, 2000 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 400 ppm, 1610 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 400 ppm, 1610 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,200 ppm [LEL]

Potential Symptoms: Irritation of eyes, skin, respiratory system; dizziness, drowsiness; in animals: narcosis; chemical pneumonia (by aspiration of liquid); INGES. ACUTE: Nausea

Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. Vapor/air mixtures may be explosive. NIOSH's IDLH is 10% of the lower explosive limit of methylcyclohexane.
  2. The urinary metabolites of orally administered methylcyclohexane in rabbits and rats are glucuronide conjugates of several hydroxylated derivatives. The most common metabolite in the rabbit is trans-4-methylcyclohexanol, and the most common in the rat is 2(trans)-hydroxy-4(cis)-methylcyclohexanol.
  3. The amount of methylcyclohexane in JP-4 jet fuel (>7%) is much greater than in automotive gasoline (0.46-0.58 %).

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Methylcyclohexane.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Methylcyclohexane.
  • Elliott, T.H., Tao, R.C.C. and Williams, R.T.: The metabolism of methylcyclohexane. Biochem. J. 95: 70-76, 1965.
  • Parnell, M.J., Henningsen, G.M., Hixson, C.J., Yu, K.O., McDonald, G.A. and Serve, M.P.: The metabolism of methylcyclohexane in Fischer 344 rats. Chemosphere 17(7): 1321-1327, 1988.
  • Pohanish, R.P. (editor): Methylcyclohexane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1546-1547.
  • No author: Identifying hydrocarbons. In, Forensics Primer: An Introduction to Environmental Forensic Geochemistry. ZymaX Forensics, Division of ZymaX™ Envirotechnology, Inc.

Date Last Revised: 06/21/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 4 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1500 [127 KB PDF, 8 pages])
    method classification: Fully Validated

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