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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1-Methoxy-2-acetoxypropane; 2-methoxy-1-methylethyl ester acetic acid; 1-Methoxy-2-propanol acetate; 1-Methoxy-2-propyl Acetate; PGMEA; 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; Propylene glycol monomethyl ether acetate

OSHA IMIS Code Number: P218 IMIS Propylene glycol monomethyl ether acetate prior to 2/13/08

Chemical Abstracts Service (CAS) Registry Number: 108-65-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI8925000

Chemical Description and Physical Properties:
    colorless flammable liquid with sweet ether-like odor; mixes with water. Soluble in most solvents.
    molecular formula: C6H12O3
    molecular weight: 132.16
    boiling point: 145.8°C
    flash point: 42.2°C
    melting point: <-67°C
    vapor pressure: 0.5 kPa @ 20°C

Health Factors

Potential Symptoms: Eye, nose, throat and skin irritation; cough, sore throat; headache, nausea, dizziness, drowsiness; INGES. ACUTE: Abdominal pain, diarrhea; unconsciousness

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Narcosis (HE8); Acute kidney and lung damage (HE4)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:
  1. OSHA does not have a PEL for propylene glycol monomethylether acetate (PGMEA).
  2. Because of the rapid hydrolysis of PGMEA by blood and liver esterases, it has been suggested that the toxicology of PGME can serve as a surrogate for PGMEA, except for possible additional upper respiratory irritation by acetic acid resulting from the hydrolysis of PGMEA.
  3. 14C-labeled PGMEA given to rats by either the oral or inhalational routes was metabolized >50% to carbon dioxide. About 25% of the dose was excreted in the urine as both free and conjugated 1-methoxy-2-propanol, and as the O-demethylated metabolite, 1,2-propanediol.
Date Last Revised: 09/05/2006

Literature Basis:
  • International Chemical Safety Cards (WHO/IPCS/ILO): Propylene glycol monomethyl ether acetate.
  • Domoradzki, J.Y., Brzak, K.A. and Thornton, C.M.: Hydrolysis kinetics of Propylene glycol monomethyl ether acetate in rats in vivo and in rat and human tissues in vitro. Toxicol. Sci. 75(1): 31-39, 2003.
  • Miller, R.R., Hermann, E.A., Young, J.T., Calhoun, L.L. and Kastl, P.E.: Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies. Toxicol. Appl. Pharmacol. 75(3): 521-530, 1984.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 10 Liters   
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 99)
    method classification: Fully Validated
    note: Samples should be refrigerated upon receipt by the laboratory.

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