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Synonyms: 1-Methoxy-2-acetoxypropane; 2-methoxy-1-methylethyl ester acetic acid; 1-Methoxy-2-propanol acetate; 1-Methoxy-2-propyl Acetate; PGMEA; 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; Propylene glycol monomethyl ether acetate
OSHA IMIS Code Number: P218 IMIS Propylene glycol monomethyl ether acetate prior to 2/13/08
Chemical Abstracts Service (CAS) Registry Number: 108-65-6
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI8925000
Chemical Description and Physical Properties:
colorless flammable liquid with sweet ether-like odor; mixes with water. Soluble in most solvents.
Potential Symptoms: Eye, nose, throat and skin irritation; cough, sore throat; headache, nausea, dizziness, drowsiness; INGES. ACUTE: Abdominal pain, diarrhea; unconsciousness
molecular formula: C6H12O3
molecular weight: 132.16
boiling point: 145.8°C
flash point: 42.2°C
melting point: <-67°C
vapor pressure: 0.5 kPa @ 20°C
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Narcosis (HE8); Acute kidney and lung damage (HE4)
Affected Organs: Eyes, skin, respiratory system, CNS
Date Last Revised: 09/05/2006
- OSHA does not have a PEL for propylene glycol monomethylether acetate (PGMEA).
- Because of the rapid hydrolysis of PGMEA by blood and liver esterases, it has been suggested that the toxicology of PGME can serve as a surrogate for PGMEA, except for possible additional upper respiratory irritation by acetic acid resulting from the hydrolysis of PGMEA.
- 14C-labeled PGMEA given to rats by either the oral or inhalational routes was metabolized >50% to carbon dioxide. About 25% of the dose was excreted in the urine as both free and conjugated 1-methoxy-2-propanol, and as the O-demethylated metabolite, 1,2-propanediol.
Laboratory Sampling/Analytical Method:
- International Chemical Safety Cards (WHO/IPCS/ILO): Propylene glycol monomethyl ether acetate.
- Domoradzki, J.Y., Brzak, K.A. and Thornton, C.M.: Hydrolysis kinetics of Propylene glycol monomethyl ether acetate in rats in vivo and in rat and human tissues in vitro. Toxicol. Sci. 75(1): 31-39, 2003.
- Miller, R.R., Hermann, E.A., Young, J.T., Calhoun, L.L. and Kastl, P.E.: Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies. Toxicol. Appl. Pharmacol. 75(3): 521-530, 1984.
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters
maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 99)
method classification: Fully Validated
note: Samples should be refrigerated upon receipt by the laboratory.
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