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Chemical Sampling Information (CSI)
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General Description

Synonyms: Dowtherm® 209; 1-Methoxy-2-hydroxypropane; 1-Methoxy-2-propanol; 2-Methoxy-1-methylethanol; PGME; Propylene glycol methyl ether; Propylene glycol monomethyl ether

OSHA IMIS Code Number: 2210

IMIS Name History: Propylene glycol monomethyl ether prior to 2/13/08

Chemical Abstracts Service (CAS) Registry Number: 107-98-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UB7700000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 3092 129

NIOSH Pocket Guide to Chemical Hazards, Propylene glycol monomethyl ether: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) : 100 ppm, 369 mg/m3 TWA; 150 ppm, 553 mg/m3 STEL

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 360 mg/m3 TWA; 150 ppm, 540 mg/m3 STEL (REL listed under Propylene glycol monomethyl ether)

Health Factors

Potential Symptoms: Eye, nose, throat and skin irritation; cough, sore throat, bronchitis; headache, nausea, dizziness, drowsiness, incoordination; vomiting, diarrhea; SKIN ABS.

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Acute kidney and lung damage (HE4).

Affected Organs: Eyes, skin, respiratory system, CNS.

Notes:

  1. OSHA does not have a PEL for this chemical. EPA's reference concentration for chronic inhalation exposure (RfC) is 2 mg/m3.
  2. A NOAEL of at least 150 ppm for eye irritation has been suggested.
  3. It is excreted in the urine as both free and conjugated 1-methoxy-2-propanol, and as the O-demethylated metabolite, 1,2-propanediol.
  4. Although it is absorbed through the skin, in vitro studies with human skin indicate that absorption occurs at a much slower rate than absorption of the ethylene glycol derivatives, 2-ethoxyethanol and especially 2-butoxyethanol.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Propylene glycol monomethyl ether.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Propylene glycol monomethyl ether.
  • EPA Integrated Risk Information System: Propylene glycol monomethyl ether (PGME) (CASRN 107-98-2).
  • Devanthéry, A., Berode, M. and Droz, P.O.: Propylene glycol monomethyl ether occupational exposure. 3. Exposure of human volunteers. Int. Arch. Occup. Environ. Health 75(4): 203-208, 2002.
  • Emmen, H.H., Muijser, H., Arts, J.H. and Prinsen, M.K.: Human volunteer study with PGME: eye irritation during vapor exposure. Toxicol. Lett. 140-141: 249-259, 2003.
  • Pohanish, R.P. (editor): Propylene Glycol Monomethyl Ether. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1974-1976.
  • Wilkinson, S.C. and Williams, F.M.: Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. Int. Arch. Occup. Environ. Health 75(8): 519-527, 2002.

Date Last Revised: 03/04/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 10 Liters   
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 99)
    method classification: Fully Validated
    note: Samples should be refrigerated upon receipt by the laboratory.

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