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Chemical Sampling Information (CSI)
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General Description

Synonyms: Methacrylic acid (glacial), Methacrylic acid (inhibited), alpha-Methacrylic acid, 2-Methylacrylic acid, 2-Methylpropenoic acid; 2-Methylene propionic acid

OSHA IMIS Code Number: M339

Chemical Abstracts Service (CAS) Registry Number: 79-41-4

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OZ2975000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2531 153P (inhibited)

NIOSH Pocket Guide to Chemical Hazards, Methacrylic acid: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 20 ppm; 70 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 20 ppm, 70 mg/m3 TWA; Skin

Health Factors

Potential Symptoms: Irritation of eyes, skin, mucous membranes; eye, skin burns; cough, shortness of breath, labored breathing, pulmonary edema (may be delayed); skin blisters, loss of vision; INGES ACUTE: burning sensation; weakness; abdominal cramps, pain; SKIN ABS

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Respiratory effects---pulmonary edema (HE11)

Affected Organs: Eyes, skin, respiratory system

Notes:

  1. OSHA does not have a PEL for methacrylic acid.
  2. In 13-week inhalation studies with mice, the NOAEL of methacrylic acid was reported to be 352 mg/m3.
  3. Methacrylic acid is a substrate of the "valine pathway," being metabolized to carbon dioxide and water via methylmalonyl-CoA and succinyl-CoA (substrates of the citric acid cycle).
  4. Although esters of methacrylic acid are skin sensitizers, contact dermatitis from methacrylic acid, itself, appears to be primarily due to a concentration-related irritation, ranging in intensity from mildly irritative to severely corrosive.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Methacrylic acid.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Methacrylic acid.
  • Cosmetic Ingredient Review Expert Panel: Final report of the safety assessment of methacrylic acid. Int. J. Toxicol. 24(Suppl. 5): 33-51, 2005.
  • Greim, H., et al.: Assessment of structurally related chemicals: toxicity and ecotoxicity of acrylic acid and acrylic acid alkyl esters (acrylates), methacrylic acid and methacrylic acid alkyl esters (methacrylates). Chemosphere 31(2): 2637-2659, 1995.
  • Lazarov, A.: Sensitization to acrylates is a common adverse reaction to artificial fingernails. J. Eur. Acad. Dermatol. Venereol. 21(2): 169-174, 2007.
  • Pohanish, R.P. (editor): Methacrylic Acid. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1490-1491.

Date Last Revised: 05/03/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Two Anasorb 708 Tubes in series
    analytical solvent: Methanol
    maximum volume: 24 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA PV2005)
    method classification: Partially Validated

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