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Manganese Tetroxide (as Mn)

General Description

  • Synonyms: Manganese oxide; Manganomanganic oxide; Trimanganese tetraoxide; Trimanganese tetroxide
  • OSHA IMIS Code Number: M101
  • Chemical Abstracts Service (CAS) Registry Number: 1317-35-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OP0895000
  • NIOSH Pocket Guide to Chemical Hazards, Manganese Tetroxide (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2012): Manganese [7439-96-5], elemental and inorganic compounds, as Mn: 0.2 mg/m3 (respirable particulate matter), 0.1 mg/m3 (inhalable particulate matter); A4
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; Appendix D - Substances With No Established RELs

Health Factors

  • Potential symptoms: Asthenia, insomnia, mental confusion; low-back pain; vomiting; malaise, lassitude; kidney damage; cough, pneumonitis; eye, skin redness; neurological and mental disorders (manganism).
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Cumulative CNS damage (HE7); Lung damage---Acute (HE11) and Cumulative (HE10).
  • Affected organs: Respiratory system, CNS, blood, kidneys.
  • Notes:
    1. Inhalational toxicokinetic studies with rats indicate achievement of higher levels of manganese in the olfactory bulb and striatal brain areas with Mn sulfate (soluble) than with Mn tetroxide (relatively insoluble).
  • Date Last Revised: 06/28/2004
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Manganese Tetroxide (as Mn).
    • International Chemical Safety Cards (WHO/IPCS/ILO): Manganese oxide.
    • EPA Air Toxics Website: Manganese Compounds. U.S. Environmental Protection Agency Technology Transfer Network.
    • Dorman, D.C., Struve, M.F., James, R.A., Marshall, M.W., Parkinson, C.U. and Wong, B.A.: Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure. Toxicol. Appl. Pharmacol. 170(2): 79-87, 2001.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Mixed Cellulose Ester Filter (MCEF) 0.8 microns
  • maximum volume: 960 Liters
  • minimum volume: 480 Liters
  • maximum flow rate: 2.0 L/min
  • current analytical method: Atomic Absorption Spectroscopy; AAS
  • method reference: OSHA Analytical Method (OSHA ID-121)
  • method classification: Fully Validated
  • alternate analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
  • method reference: OSHA Analytical Method (OSHA ID-125G)
  • method classification: Fully Validated
  • note: Analytical method does not distinguish between dust and fume. When an analysis of a compound is requested, an elemental analysis is performed and reported as Manganese.

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