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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2-Methylpropyl Isobutyrate; 2-Methylpropyl 2-Methylpropanoate; 2-Methylpropyl 2-Methylpropionate; Isobutyric Acid, Isobutyl Ester

OSHA IMIS Code Number: 1537

Chemical Abstracts Service (CAS) Registry Number: 97-85-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: NQ5250000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2528 130

Chemical Description and Physical Properties:

clear liquid
molecular weight:144.21
molecular formula: C8H16O2
boiling point: 148°C
flash point: 37°C (open cup)

Health Factors

Potential Symptoms: Irritation of eyes, respiratory tract, skin; drowsiness; dry, cracked skin, dermatitis (with prolonged or repeated skin contact)

Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. OSHA does not have a PEL for isobutyl isobutyrate.
  2. Isobutyl isobutyrate is listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515).
  3. The NOAEL was reported to be 1000 mg/kg/day, the highest dose tested in rats given isobutyl isobutyrate in corn oil orally 7 days/week for 18 weeks.

Literature Basis:

  • Drake, J.J., Butterworth, K.R., Gaunt, I.F. and Grasso, P.: Short-term toxicity study of isobutyl isobutyrate in rats. Food Cosmet. Toxicol. 16(4): 337-342, 1978.
  • Eastman Product Safety and Health: Material Safety Data Sheet: Propanoic acid, 2-methyl-, 2-methylpropyl ester (revised 08/26/2004), 6 pp.

Date Last Revised: 09/12/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (99:1) Carbon Disulfide: DMF
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2090)
    method classification: Partially Validated

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