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Chemical Sampling Information (CSI)
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General Description

Synonyms: Isobutyl ester of acetic acid; 2-Methylpropyl acetate; 2-Methylpropyl ester of acetic acid; beta-Methylpropyl ethanoate

OSHA IMIS Code Number: 1534

Chemical Abstracts Service (CAS) Registry Number: 110-19-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI4025000

Department of Transportation Regulation Number (49 CFR 172.101) and 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 1213 129

NIOSH Pocket Guide to Chemical Hazards - Isobutyl acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more


Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL) - General Industry
See 29 CFR 1910.1000 Table Z-1

150 ppm (700 mg/m3) TWA

HE15

Eye and respiratory irritation

OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A

150 ppm (700 mg/m3) TWA

HE15

Eye and respiratory irritation

OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards

150 ppm (700 mg/m3) TWA

HE15

Eye and respiratory irritation

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

150 ppm (700 mg/m3) TWA

HE7

Headache, drowsiness
Target organs: Brain, central nervous system

HE15 Eye and respiratory irritation

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)

150 ppm (713 mg/m3) TWA

HE15

Eye and respiratory irritation

CAL/OSHA PEL

150 ppm (700 mg/m3) TWA

HE15

Eye and respiratory irritation

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC) carcinogenic classification: Not listed

U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 1,300 ppm (10% LEL)

Notes on Other Potential Health Effects and Hazards

  1. Vapor/air mixtures may be explosive (NIOSH/IPCS 2003).

Date Last Revised: 09/06/2012

Literature Basis

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isobutyl Acetate. 2001.
  • NIOSH: Occupational Health Guideline for Isobutyl Acetate. September 1978.
  • NIOSH/IPCS: International Chemical Safety Cards - Isobutyl Acetate. November 26, 2003.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 12 Liters   
    maximum flow rate:
    0.05 L/min (TWA)
    maximum volume: 0.75 Liter   
    maximum flow rate: 0.05 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 1009)
    method classification: Fully Validated

  • sampling media: Diffusive Sampler:
    • 3M 3520 Organic Vapor Monitor;
    • SKC 575-002 Passive Sampler
    analytical solvent: Carbon Disulfide
    minimum time: 15 to 240 Minutes
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 1009)
    method classification: Fully Validated
    note: Persons using diffusive samplers to monitor workplace air must ensure that the sampling devices are properly closed before transporting such devices to the laboratory for analysis. The device will continue to sample until properly closed. Diffusive sampler accessories used for analysis of samplers must be included with transported samples. Persons using such devices must provide sampling-site station barometric pressure and temperature to the analytical laboratory to improve accuracy of sampling results.

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    alternate analytical solvent: (99:1) Carbon Disulfide: Dimethylformamide
    alternate analytical solvent: (95:5) Methylene Chloride: Methanol
    maximum volume: 10 Liters   
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1450 [107 KB PDF, 6 pages])
    method classification: Fully Validated
    note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory.

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