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Chemical Sampling Information (CSI)
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General Description

Synonyms: Fermentation amyl alcohol; Isobutylcarbinol; Isopentyl alcohol; 2-Methyl-4-butanol; 3-Methyl-1-butanol

OSHA IMIS Code Number: 1532

Chemical Abstracts Service (CAS) Registry Number: 123-51-3

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EL5425000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1105 129

NIOSH Pocket Guide to Chemical Hazards, Isoamyl alcohol (primary): chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 -- 100 ppm, 360 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 360 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 360 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 100 ppm, 361 mg/m3 TWA; 125 ppm, 452 mg/m3 STEL

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 360 mg/m3 TWA; 125 ppm, 450 mg/m3 STEL

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm

Potential Symptoms: Irritation of eyes, skin, nose, throat; headache; dizziness; sore throat; cough, dyspnea; nausea, vomiting, diarrhea; skin cracking; in animals: narcosis; INGES. ACUTE: Abdominal pain, burning sensation; weakness, unconsciousness

Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16) Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. Explosive vapor/air mixtures of isoamyl alcohol may be formed above 45°C.
  2. Isoamyl alcohol is listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515).
  3. Studies of the inhalational toxicity of isoamyl alcohol in pregnant rats and rabbits reported a NOAEL of 2.5 mg/liter (~700 ppm). No embryotoxicity or fetotoxicity was reported for the highest concentration tested, 10 mg/liter.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Isoamyl alcohol (primary).
  • International Chemical Safety Cards (WHO/IPCS/ILO): Isoamyl alcohol.
  • Klimisch, H.-J. and Hellwig, J.: Studies on the prenatal toxicity of 3-methyl-1-butanol and 2-methyl-1-propanol in rats and rabbits following inhalation exposure. Fundam. Appl. Toxicol. 27(1): 77-89, 1995.
  • Pohanish, R.P. (editor): Isoamyl Alcohol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1320-1322.

Date Last Revised: 11/15/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Carbon Disulfide:Isopropanol
    alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min (TWA)
    maximum volume: 3 Liters
    maximum flow rate: 0.2 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1402 [24 KB PDF, 4 pages])
    method classification: Partially Validated

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