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Chemical Sampling Information (CSI)
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General Description

OSHA IMIS Code Number: 1515

Chemical Abstracts Service (CAS) Registry Number: 7553-56-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: NN1575000

NIOSH Pocket Guide to Chemical Hazards, Iodine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 -- 0.1 ppm, 1 mg/m3 Ceiling

Construction Industry: 29 CFR 1926.55 Appendix A -- 0.1 ppm, 1 mg/m3 Ceiling

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.1 ppm, 1 mg/m3 Ceiling

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 1 mg/m3 Ceiling

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 ppm, 1 mg/m3 Ceiling

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2 ppm

Potential Symptoms: Eye, skin, nose, throat irritation; lacrimation; headache; cough, sore throat, tight chest, pulmonary edema (may be delayed); skin, eye pain, stains, and burns; blurred vision; rash, cutaneous hypersensitivity, joint swelling and pain; deficiency of thyroid hormones; iodism; INGES ACUTE: (small doses) Salivation, excessive tearing, swelling of eyelids and salivary glands; metallic taste; fever, enlarged lymph glands; (larger doses) burning sensation in throat; abdominal cramps, vomiting, diarrhea; shock or collapse

Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)

Affected Organs: Respiratory system, eyes, skin, CNS, cardiovascular system


  1. Iodine is an effective drinking water disinfectant for temporary residents of areas where municipal water treatment is not available or not reliable, but goiter has been reported in Peace Corps workers using this method in Africa.
  2. Iodine-induced goiter may occur in patients using the iodine-containing drug amiodarone. Patients taking lithium or those with a history of treatment with interferon-a may also be at increased risk for iodine-induced hypothyroidism.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Iodine.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Iodine.
  • Backer, H. and Hallowell, J.: Use of iodine for water disinfection: iodine toxicity and maximum recommended dose. Environ. Health Perspect. 108(8): 679-684, 2000.
  • Pohanish, R.P. (editor): Iodine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1305-1306.

Date Last Revised: 06/10/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Carbon Bead Tube impregnated with Alkali Metal Hydroxide (SKC No. 226-80 or equivalent)
    maximum volume: 7.5 Liters
    maximum flow rate: 0.5 L/min (Ceiling)
    current analytical method: Ion Chromatography/Pulsed Electrochemical Detector; IC/PED
    current method reference: OSHA Analytical Method (OSHA ID-212)
    current method classification: Fully Validated
    alternative analytical method: Ion Specific Electrode; ISE
    alternative method reference: OSHA Analytical Method (OSHA ID-212)
    alternative method classification: Fully Validated
    note: Humidity at the sampling site needs to be assessed prior to the actual sampling. If it is anticipated to be greater then 50%, please contact the Salt Lake Technical Center for further instructions. Submit as separate sample. When the analysis of this compound is requested, analysis for Iodide is performed and reported as Iodine.

On-Site Sampling Techniques/Methods:

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 9L
    sampling information: 1 to 2 strokes
    upper measurement limit: 12 ppm
    detection limit: 0.04 ppm
    overall uncertainty: 16% for 0.2 to 1.2 ppm, 8% for 1.2 to 12 ppm
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 80
    sampling information: 1 to 4 strokes
    upper measurement limit: 48 ppm
    detection limit: approximately 0.3 ppm
    overall uncertainty: 16%
    method reference: on-site air secondary (manufacturer)

Wipe Sampling Method:

  • note: OSHA personnel should contact the Salt Lake Technical Center for media.

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