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Synonyms: Roundup®; glyphosate; 2-(p-Chlorophenyl)phenylacetyl-1,3-indandione; N-(phosphonomethyl)glycine
OSHA IMIS Code Number: R106
IMIS Name History: Roundup® prior to 11/13/06
Chemical Abstracts Service (CAS) Registry Number: 38641-94-0
Other Chemical Abstracts Service (CAS) Registry Numbers: 1071-83-6 (glyphosate)
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MC1080000 (Glyphosate isopropylamine salt); MC1075000 (N-(phosphonomethyl)Glycine)
Chemical Description and Physical Properties:
crystalline solid, very soluble in water
molecular weight: 228.22
molecular formula: C3H9N-C3H8NO5P
melting point: 184.5°C
Potential Symptoms: Eye, skin irritation. INGES ACUTE: Sore throat, nausea, vomiting, diarrhea; respiratory distress, pulmonary edema, shock (systolic blood pressure <90 mm Hg); low serum bicarbonate, acidosis, hyperkalemia, arrhythmia.
Health Effects: Irritation-Eyes---Marked (HE14), Skin---Mild (HE-16); with acute ingestion, pulmonary edema (HE-11) and renal failure (HE-4)
Affected Organs: Eyes, skin, respiratory system, cardiovascular system, kidneys
- OSHA does not have a PEL for glyphosate or its isopropylamine salt (Roundup).
- Glyphosate is an herbicide that inhibits the synthesis of aromatic amino acids in plants by inhibiting enolpyruvylshikimate phosphate synthase, an enzyme existing only in plants.
- Fatal intoxication has occurred from suicidal ingestion of Roundup.
- Some of the toxic effects of Roundup may be due to surfactant in its formulations rather than due to glyphosate.
- Glyphosate is excreted unchanged in the urine.
- International Chemical Safety Cards (WHO/IPCS/ILO): Glyphosate.
- U.S. EPA Integrated Risk Information System: Glyphosate (CASRN 1071-83-6).
- Lee, H.L., Chen, K.W., Chi, C.H., Huang, J.J. and Tsai, L.M.: Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases. Acad. Emerg. Med. 7(8): 906-910, 2000.
- Pohanish, R.P. (editor): Glyphosate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1214-1215.
- Stella, J. and Ryan, M.: Glyphosate herbicide formulation: a potentially lethal ingestion. Emerg. Med. Australas. 16(3): 235-239, 2004.
- Williams, G.M., Kroes, R. and Munro, I.C.: Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 31(2 Pt. 1): 117-165, 2000.
Date Last Revised: 06/28/2005
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Glass Fiber Filter (37 mm)
analytical solvent: 0.025M Borate Buffer
maximum volume: 100 Liters
maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2067)
method classification: Partially Validated
Conditions: Column: NH2; Mobile Phase: 50:50 Acetonitrile: Water and 0.05 M Potassium Phosphate Monobasic; Fluorescence Detector Wavelength: 206 nm; 206 nm Ex; 320 nm Em; UV Detector Wavelength: 206 nm
- Limit the amount of bulk submitted to one gram or one mL.
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