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Chemical Sampling Information (CSI)
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General Description

Synonyms: Roundup®; glyphosate; 2-(p-Chlorophenyl)phenylacetyl-1,3-indandione; N-(phosphonomethyl)glycine

OSHA IMIS Code Number: R106

IMIS Name History:
Roundup® prior to 11/13/06

Chemical Abstracts Service (CAS) Registry Number: 38641-94-0

Other Chemical Abstracts Service (CAS) Registry Numbers: 1071-83-6 (glyphosate)

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MC1080000 (Glyphosate isopropylamine salt); MC1075000 (N-(phosphonomethyl)Glycine)

Chemical Description and Physical Properties:

crystalline solid, very soluble in water
molecular weight: 228.22
molecular formula: C3H9N-C3H8NO5P
melting point: 184.5°C

Health Factors

Potential Symptoms: Eye, skin irritation. INGES ACUTE: Sore throat, nausea, vomiting, diarrhea; respiratory distress, pulmonary edema, shock (systolic blood pressure <90 mm Hg); low serum bicarbonate, acidosis, hyperkalemia, arrhythmia.

Health Effects: Irritation-Eyes---Marked (HE14), Skin---Mild (HE-16); with acute ingestion, pulmonary edema (HE-11) and renal failure (HE-4)

Affected Organs: Eyes, skin, respiratory system, cardiovascular system, kidneys

Notes:

  1. OSHA does not have a PEL for glyphosate or its isopropylamine salt (Roundup).
  2. Glyphosate is an herbicide that inhibits the synthesis of aromatic amino acids in plants by inhibiting enolpyruvylshikimate phosphate synthase, an enzyme existing only in plants.
  3. Fatal intoxication has occurred from suicidal ingestion of Roundup.
  4. Some of the toxic effects of Roundup may be due to surfactant in its formulations rather than due to glyphosate.
  5. Glyphosate is excreted unchanged in the urine.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Glyphosate.
  • U.S. EPA Integrated Risk Information System: Glyphosate (CASRN 1071-83-6).
  • Lee, H.L., Chen, K.W., Chi, C.H., Huang, J.J. and Tsai, L.M.: Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases. Acad. Emerg. Med. 7(8): 906-910, 2000.
  • Pohanish, R.P. (editor): Glyphosate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1214-1215.
  • Stella, J. and Ryan, M.: Glyphosate herbicide formulation: a potentially lethal ingestion. Emerg. Med. Australas. 16(3): 235-239, 2004.
  • Williams, G.M., Kroes, R. and Munro, I.C.: Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 31(2 Pt. 1): 117-165, 2000.

Date Last Revised: 06/28/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Glass Fiber Filter (37 mm)
    analytical solvent: 0.025M Borate Buffer
    maximum volume: 100 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA PV2067)
    method classification: Partially Validated

Conditions: Column: NH2; Mobile Phase: 50:50 Acetonitrile: Water and 0.05 M Potassium Phosphate Monobasic; Fluorescence Detector Wavelength: 206 nm; 206 nm Ex; 320 nm Em; UV Detector Wavelength: 206 nm

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.

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