A study of the disposition of radiolabeled glycidol in rats indicated that approximately ¼ to ⅓ of the administered radioactivity (oral or intravenous) was expired as CO2 and 40-48% was excreted in the urine as 15 unidentified metabolites.
In 2-year carcinogenicity studies, oral glycidol induced neoplasms in multiple tissues of rats (37.5 or 75 mg/kg/day) and mice (25 or 50 mg/kg/day), including gliomas of the brain (rarely seen with other chemical carcinogens). Higher doses in shorter-term studies caused brain lesions, testicular atrophy, and kidney damage.
Glycidol was reported to be selectively immunosuppressive in mice, decreasing host resistance to a melanoma tumor model, but not to Listeria monocytogenes or Streptococcus pneumoniae.
Glycidol showed some potential as prion disinfectant in a study with a prion protein that causes scrapie (a spongiform encephalitis) in mice.
International Chemical Safety Cards (WHO/IPCS/ILO): Glycidol.
No Author: Glycidol (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
NTP: NTP toxicology and carcinogenesis studies of glycidol (CAS No. 556-52-5) in F344/N rats and B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser.374: 1-229, 1990.
Guo, T.L., et al.: Glycidol modulation of the immune responses in female B6C3F1 mice. Drug Chem. Toxicol.23(3): 433-457, 2000.
Nomeir, A.A., et al.: Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J. Toxicol. Environ. Health44(2): 203-217, 1995.
Pohanish, R.P. (editor): Glycidol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1210-1212.
Sills, R.C., Hailey, J.R., Neal, J., Boorman, G.A., Haseman, J.K. and Melnick, R.L.: Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. Toxicol. Pathol.27(5): 589-599, 1999.
Yamamoto, M., Horiuchi, M., Ishiguro, N., Shinagawa, M., Matsuo, T. and Keneko, K.: Glycidol degrades scrapie mouse prion protein. J. Vet. Med. Sci.63(9): 983-990, 2001.
Date Last Revised: 10/12/2005
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
Charcoal Tube (100/50 mg sections, 20/40 mesh)
maximum volume: 50 Liters
maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/FID
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