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Chemical Sampling Information (CSI)
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General Description

Synonyms: Adrucil; Efudex; Fluoroplex; 5-Fluoropyrimidine-2,4-dione; Fluorouracil; FU; 5-FU

OSHA IMIS Code Number: F127

Chemical Abstracts Service (CAS) Registry Number: 51-21-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: YR0350000; 85639

Chemical Description and Physical Properties:

crystals from water or methanol-ether
molecular weight: 130.08
molecular formula: C4H3FN2O2

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 3, not classifiable as to its carcinogenicity to humans

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
    analytical solvent: Methanol
    maximum volume: 200 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/U.
    method reference: 2 (OSHA In-house File)
    method classification: Partially Validated

Conditions: Methanol extraction; HPLC; Zorbax NH2 column; 40% hexane, 10% isopropanol, 50% methanol; 1.5 mL/min; 266 nm, 254 nm; RT 4.9 min; DL 0.5ng/inj C/P YC 5/88

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