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Chemical Sampling Information (CSI)
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General Description

Synonyms: Methacrylic acid, ethyl ester; ethyl 2-methylacrylate; ethyl 2-methyl-2-propenoate; Rhoplex AC-33; 2-propenoic acid, 2-methyl-ethyl ester

OSHA IMIS Code Number: E115

Chemical Abstracts Service (CAS) Registry Number: 97-63-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OZ4550000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2277 130P, inhibited; 2277 130P, stabilized

Chemical Description and Physical Properties:

clear or light yellow liquid, acrylate odor
molecular weight: 114.14
vapor pressure: 2 kPa @ 20°C
molecular formula: C6H10O2
boiling point: 117°C
melting point: -75°C
flash point: 21°C

Health Factors

Potential Symptoms: Irritation of eyes, skin, respiratory system; lacrimation; cough, sore throat; dizziness, lightheadedness; sensitization, dermatitis; INGES. ACUTE: Abdominal pain, nausea, vomiting, diarrhea

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. OSHA does not have a PEL for ethyl methacrylate.
  2. Vapor/air mixtures may be explosive.
  3. Patch testing of 243 patients with a history of exposure to various acrylates identified 18 (7.4%) who had an allergic reaction to ethyl methacrylate.
  4. Irritation of the nasal mucosa may be due in part to hydrolysis of ethyl methacrylate to methacrylic acid by carboxylesterase, high levels of which have been demonstrated in rat olfactory mucosa.
  5. Treatment of rats with ethyl methacrylate in their drinking water at concentrations of 0.1, 0.2 and 0.5% for 60 days was reported to cause myelinopathy, consisting of clusters of axonal enlargements in the spinal cord and spongiform alterations in white-matter tracts in the brainstem and forebrain, as well as abnormal myelin sheaths in sciatic nerve axons.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl methacrylate.
  • Abou-Donia, M.B., et al.: Neurotoxicity of ethyl methacrylate in rats. Toxicol. Environ. Health A 59(2): 97-118, 2000.
  • Cosmetic Ingredient Review Expert Panel: Amended final report on the safety assessment of ethyl methacrylate. Int. J. Toxicol. 21(Suppl. 1): 63-79, 2002.
  • Kanerva, L., Jolanki, R. and Estlander, T.: 10 years of patch testing with the (meth)acrylate series. Contact Dermatitis 37(6): 255-258, 1997.
  • McCarthy, T.J. and Witz, G.: Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology 116(1-3): 153-158, 1997.
  • Olson, M.J., Martin, J.L., LaRosa, A.C., Brady, A.N. and Pohl, L.R.: Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. J. Histochem. Cytochem. 41(2): 307-311, 1993.
  • Pohanish, R.P. (editor): Ethyl methacrylate. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1117-1118.

Date Last Revised: 06/20/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2100)
    method classification: Partially Validated

  • sampling media: Coated Charcoal Tube (110/55 mg sections; 20/40 mesh); Coating is 10% (w/w) 4-t-Butylcatechol.
    analytical solvent: Carbon Disulfide
    alternate solvent: Toluene
    maximum volume: 3 Liters
    maximum flow rate: 0.05 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Not Validated

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