Health Effects: Cumulative liver and kidney damage (HE3); CNS effects (HE7); Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15)
Affected Organs: Kidneys, liver, eyes, skin, CNS, cardiovascular system
A study of 221 litigant hazardous clean-up workers exposed to ethylene dichloride (mean, 28 months; median 13 months) without PPE indicated a number of neuropsychological deficits, such as processing speed, attention, cognitive flexibility, motor coordination and speed, verbal memory, verbal fluency, and visuo-spacial abilities, as well as disturbed mood, impaired color vision, contrast sensitivity and dry eye syndrome.
Metabolized by cytochrome P-450 2E1, a liver enzyme induced by ethanol consumption.
Bowler, R.M., Gysens, S. and Hartney, C.: Neuropsychological effects of ethylene dichloride exposure. Neurotoxicology 24(4-5): 553-562, 2003.
Guengerich, F.P., Kim, D.H. and Iwasaki, M.: Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4(2): 168-179, 1991.
Pohanish, R.P. (editor): Ethylene Dichloride. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp.1085-1087.
Date Last Revised: 06/04/2004
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
Charcoal Tube (100/50 mg sections, 20/40 mesh)
maximum volume: 10 Liters
maximum flow rate: 0.2 L/min (TWA)
maximum volume: 3 Liters
maximum flow rate: 0.2 L/min (STEL)
maximum time: 5 Minutes
maximum flow rate: 0.2 L/min (Ceiling)
maximum time: 5 Minutes
maximum flow rate: 0.2 L/min (Peak)
current analytical method: Gas chromatography; GC/FID - NIOSH Gas chromatography; GC/ECD - OSHA
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