Metabolized in the liver primarily by cytochrome P450 2E1 and conjugation with glutathione.
Serious toxic interactions between ethylene dibromide inhalation (20 ppm) and the drug disulfiram (an inhibitor of CYP2E1) have been reported in rat carcinogenicity studies.
Effects on sperm reported for workers exposed to peak levels less than 0.3 ppm.
Letz, G.A., Pond, S.M., Osterloh, J.D., Wade, R.L. and Becker, C.E.: Two fatalities after acute occupational exposure to ethylene dibromide. JAMA252(17): 2428-2431, 1984 (symptoms of fatal exposure).
Ratcliffe, J.M., Schrader, S.M., Steenland, K., Clapp, D.E., Turner, T. and Hornung, R.W.: Semen quality in papaya workers with long term exposure to ethylene dibromide. Br. J. Ind. Med.44(5): 317-326, 1987 (sperm toxicity).
Wormhoudt, L.W., Ploemen, J.H., de Waziers, I., Commandeur, J.N., Beaune, P.H., van Bladeren, P.J. and Vermeulen, N.P.: Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. Chem. Biol. Interact. 101(3): 175-192, 1996 (metabolism).
Stein, H.P., Bahlman, L.J., Leidel, N.A., Parker, J.C., Thomas, A.W. and Millar, J.D.: Ethylene dibromide and disulfiram toxic interaction. Am. Ind. Hyg. Assoc. J. 39(7): A35-37, 1978 (interaction with disulfiram).
Date Last Revised: 05/20/2003
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
Charcoal Tube (100/50 mg sections, 20/40 mesh)
maximum volume: 10 Liters
maximum flow rate: 0.2 L/min (TWA)
maximum time: 5 Minutes
maximum flow rate: 0.2 L/min (Ceiling)
maximum time: 5 Minutes
maximum flow rate: 0.2 L/min (Peak)
current analytical method: Gas Chromatography; GC/ECD
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.
U.S. Department of Labor | Occupational Safety & Health Administration | 200 Constitution Ave., NW, Washington, DC 20210 Telephone: 800-321-OSHA (6742) | TTY www.OSHA.gov
Thank You for Visiting Our Website
You are exiting the Department of Labor's Web server.
The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.