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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1,2-Diaminoethane; 1,2-Ethanediamine; Ethylenediamine (anhydrous)

OSHA IMIS Code Number: 1130

Chemical Abstracts Service (CAS) Registry Number: 107-15-3

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KH8575000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1604 132

NIOSH Pocket Guide to Chemical Hazards, Ethylenediamine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 -- 10 ppm, 25 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 10 ppm, 25 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 10 ppm, 25 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 25 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 10 ppm, 25 mg/m3 TWA

Health Factors

Carcinogenic Classification:

Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,000 ppm

Potential Symptoms: Irritation of nose, respiratory system; cough, wheezing, shortness of breath; eye and skin redness, pain, burns; blurred vision; sensitization dermatitis; asthma; liver, kidney damage; INGES. ACUTE: Abdominal pain, burning sensation, shock or collapse

Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Contact dermatitis (HE3); Asthma (HE9)

Affected Organs: Skin, respiratory system, liver, kidneys

Notes:

  1. Explosive vapor/air mixtures of ethylenediamine may be formed at temperatures above 34°C.
  2. Ethylenediamine is permitted by the FDA as a secondary direct food additive for controlling microorganisms for cane-sugar mills up to 1 ppm and for beet-sugar mills up to 2 ppm in combination with specific carbamates (21 CFR 173.320).
  3. The major urinary metabolite of ethylenediamine in rats, mice and humans is N-acetylethylenediamine. In mice, the terminal half-life in plasma was reported to be 5 hours after intravenous administration and 6.8 hours after oral administration.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Ethylenediamine.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Ethylenediamine.
  • EPA Integrated Risk Information System: Ethylene diamine (CASRN 107-15-3).
  • Leung, H.-W.: Pharmacokinetics and metabolism of ethylenediamine in the Swiss Webster mouse following oral or intravenous dosing. Toxicol. Lett. 117(1-2): 107-114, 2000.
  • Pohanish, R.P. (editor): Ethylenediamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1079-1081.
  • Sasseville, D. and al-Khenaisan, S.: Occupational contact dermatitis from ethylenediamine in a wire-drawing lubricant. Contact Dermatitis 36(4): 228-229, 1997.

Date Last Revised: 05/14/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated XAD-2 Tubes (80/40 mg sections, 16/50 mesh); Coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
    analytical solvent: Dimethylformamide
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA 60)
    method classification: Fully Validated
    note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center.

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