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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2-Cyanoacrylate acid, Ethyl ester; ECA; Ethyl cyanoacrylate; Ethyl alpha-cyanoacrylate; 2-Propenoic acid, 2-cyano, ethyl ester

OSHA IMIS Code Number: E108

Chemical Abstracts Service (CAS) Registry Number: 7085-85-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UD3330050

Chemical Description and Physical Properties:

clear colorless liquid with irritating, sweet, ester-like odor
molecular weight: 125.14
vapor pressure: 0.17 mm Hg @ 20°C
molecular formula: C6H7NO2
boiling point: 54-56°C (2.6-3.0 mm Hg)

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 ppm, 1 mg/m3 TWA (TLV listed under Ethyl Cyanoacrylate)

Health Factors

Potential Symptoms: Irritation of eyes. Skin, upper respiratory tract; lacrimation, rhinorrhea; skin sensitization, dermatitis

Health Effects: Allergic contact dermatitis (HE3); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14)

Affected Organs: Eyes, skin, nails

Notes:

  1. OSHA does not have a PEL for ethyl 2-cyanoacrylate.
  2. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (a measure of upper respiratory irritation not necessarily predictive of damage) was calculated to be 0.7 ppm in both dry air and at 50% humidity.
  3. Measurement of airborne ethyl 2-cyanoacrylate at a manufacturing plant indicated some exposures above 0.7 ppm, but these were of short duration (<15 minutes).
  4. Case reports of asthma in workers exposed to cyanoacrylates, including ethyl 2-cyanoacrylate, have been reviewed (Goodman et al., 2000). From the information provided, it was not possible to determine whether these cases were due to sensitization or irritation.
  5. Above 75°, explosive vapor/air mixtures may be formed.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl 2-cyanoacrylate.
  • Bruze, M., Björkner, B. and Lepoittevin, J.-P.: Occupational contact dermatitis from ethyl cyanoacrylate. Contact Dermatitis 32(3): 156-159, 1995.
  • Constandt, L., Hecke, E.V., Naeyaert, J.M. and Goossens, A.: Screeing for contact allergy to artificial nails. Contact Dermatitis 52(2): 73-77, 2005.
  • Gagnaire, F., Marignac, B., Morel, G., Nunge, H. and Grossmann, S.: Sensory irritation due to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate in mice. Ann. Occup. Hyg. 47(4): 297-304, 2003.
  • Goodman, M., et al.: Epidemiologic study of pulmonary obstruction in workers occupationally exposed to ethyl and methyl cyanoacrylate. J. Toxicol. Environ. Health A 59(3): 135-163, 2000.
  • Paustenbach, D., Burke, M.L., Shum, M. and Kalmes, R.: Airborne concentrations of ethyl and methyl cyanoacrylate in the workplace. AIHAJ 62(1): 70-79, 2001.

Date Last Revised: 06/08/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated XAD-7 Tube (80/40 mg sections, 20/60 mesh); coating is Phosphoric Acid.
    analytical solvent: (0.2:99.8) Phosphoric Acid:Acetonitrile
    maximum volume: 12 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA 55)
    method classification: Fully Validated
    note: Samples must be kept at reduced temperature and shipped to lab cold.

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