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Ethyl Butyl Ketone

General Description

Synonyms: Butyl ethyl ketone; 3-Heptanone

OSHA IMIS code: 1100

CAS number: 106-35-4

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • sampling media: charcoal tube (100/50 mg sections, 20/40 mesh)
  • analytical solvent: (99:1) carbon disulfide:methanol
  • maximum volume: 25 L 
  • maximum flow rate: 0.2 L/min
  • current analytical method: gas chromatography; GC/FID
  • method reference: NIOSH 1301 (partially validated)

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs

OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1

50 ppm (230 mg/m3) TWA HE8 -- narcosis
HE16 -- eye and skin irritation
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
50 ppm (230 mg/m3) TWA HE8 -- narcosis
HE16 -- eye and skin irritation
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards
50 ppm (230 mg/m3) TWA HE8 -- narcosis
HE16 -- eye and skin irritation
NIOSH REL 50 ppm (230 mg/m3) TWA HE7 -- headaches, dizziness, or unconsciousness; central nervous system depression
HE8 -- narcosis
HE16 -- eye, nose, skin, throat, and lung irritation
ACGIH TLV® (1995) 50 ppm (234 mg/m3) TWA
75 ppm (350 mg/m3) STEL
HE8 -- narcosis
HE16 -- eye and skin irritation
CAL/OSHA PELs 50 ppm (230 mg/m3) TWA
75 ppm (345 mg/m3) STEL
HE8 -- narcosis
HE16 -- eye irritation

Carcinogenic classification:

  • NTP: Not listed
  • IARC: Not listed
  • EPA: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: 1,000 ppm

Notes on other potential health effects and hazards:

  1. Ethyl butyl ketone is flammable (NIOSH/IPCS 1996) and forms an explosive mixture with air (Pohanish 2002).
  2. The ACGIH documentation for TLV notes that the limit was set to minimize the potential for narcosis and irritation largely by analogy to the other ketones. The toxicology information was characterized as limited.

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Ethyl Butyl Ketone. 2016.
  • California Occupational Safety & Health Standards Board: Initial and Final Statement of Reasons. November 3, 2004.
  • Pohanish, R.P. (editor): Ethyl Butyl Ketone. In Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, pp. 1062-1064, 2002.
  • NIOSH/CEC/IPCS: International Chemical Safety CardEthyl n-Butyl Ketone. March 28, 1996.
  • NIOSH: Occupational Health Guideline for Ethyl Butyl Ketone. September 1978.

Chemical Sampling Information

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