- Synonyms: Acrylic Acid, Ethyl Ester; Ethyl acrylate (inhibited); Ethyl Propenoate; Ethoxy Carbonyl Ethylene; 2-Propenoic Acid, Ethyl Ester
- OSHA IMIS Code Number: 1050
- Chemical Abstracts Service (CAS) Registry Number: 140-88-5
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AT0700000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1917 129P (inhibited)
- NIOSH Pocket Guide to Chemical Hazards, Ethyl Acrylate: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 20 mg/m3 TWA; 15 ppm, 61 mg/m3 STEL; Appendix A4 - Not Classifiable as a Human Carcinogen
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix A - NIOSH Potential Occupational Carcinogens
- Carcinogenic Classification:
- International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm
- Potential Symptoms: Irritation of eyes, skin, respiratory system; cough, shortness of breath, pulmonary edema (may be delayed); sore throat; blurred vision; skin sensitization; [potential occupational carcinogen]; Ingestion Acute: Abdominal pain, nausea, vomiting, diarrhea
- Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)
- Affected Organs: Eyes, skin, respiratory system
- Vapor/air mixtures may be explosive.
- Skin patch testing of 192 patients with a history of exposure to various acrylates identified 16 (8.3%) who had an allergic reaction to ethyl acrylate.
- Among six acrylate esters tested for hydrolysis by carboxylesterase (porcine liver), ethyl acrylate had the highest maximum rate of acrylic acid production.
- Metabolic studies with radiolabeled ethyl acrylate in rats indicated the major metabolite to be carbon dioxide. Urinary metabolites included 3-hydroxypropionic acid and products of conjugation of acrylic acid and ethyl acrylate with glutathione.
- Ethyl acrylate is listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515). It occurs naturally in some fruits (blackberries, raspberries, pineapples and yellow passion fruit).
- NTP delisted ethyl acrylate as a suspected human carcinogen because the forestomach tumors in rats and mice appeared to arise from local tissue irritation and ulceration, rather than from a systemic toxicity, and occurred only at oral doses unlikely to be achieved by chronic human exposure.
- Ethyl acrylate remains an OSHA Select Carcinogen, due to its evaluation (Group 2B) by the IARC.
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Ethyl Acrylate.
- International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl Acrylate.
- National Toxicology Program: Report on Carcinogens. Scientific Review of Ethyl Acrylate.
- No author. Ethyl Acrylate (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
- deBethizy, J.D., Udinsky, J.R., Scribner, H.E. and Frederick, C.B.: The disposition and metabolism of acrylic acid and ethyl acrylate in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 8(4): 549-561, 1987.
- Kanerva, L., Jolanki, R. and Estlander, T.: 10 years of patch testing with the (meth)acrylate series. Contact Dermatitis 37(6): 255-258, 1997.
- McCarthy, T.J. and Witz, G.: Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology 116(1-3): 153-158, 1997.
- No authors listed: Ethyl Acrylate. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 3): 1447-1457, 1999.
- Pohanish, R.P. (editor): Ethyl acrylate. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1043-1044.
- Date Last Revised: 06/21/2006
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Coated Charcoal Tube (110/55 mg sections, 20/40 mesh) Coating is 10% 4-tert-butylcatechol.
- maximum volume: 12 Liters
- maximum flow rate: 0.05 L/min (TWA)
- maximum volume: 0.75 Liters
- maximum flow rate: 0.05 L/min (STEL)
- current analytical method: Gas Chromatography; GC/FID
- analytical solvent: Carbon Disulfide
- method reference: OSHA Analytical Method (OSHA 92)
- method classification: Fully Validated
Wipe Sampling Method:
- Charcoal pad
- note: Seal in glass vial for shipment.
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