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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1,2-Butene oxide; Ethyloxirane; Butylene Oxide (Stabilized); EBU

OSHA IMIS Code Number: E225

Chemical Abstracts Service (CAS) Registry Number: 106-88-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EK3675000

Chemical Description and Physical Properties:

colorless liquid with characteristic odor
molecular weight: 72.12
vapor pressure: 18.8 kPa @ 20°C
molecular formula: C4H8O
boiling point: 63.3°C
melting point: -130°C
flash point: -22°C

Incompatibilities: Reacts with strong oxidants causing fire hazard. Vapors mixed with air easily form explosive mixtures

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 2B, Possibly carcinogenic to humans [381 KB PDF, 171 pages]

Potential Symptoms: Eye, skin, respiratory tract irritation; sore throat; cough, shortness of breath, pulmonary edema; nausea; confusion, dizziness, lightheadedness, unconsciousness; blisters. INGES. ACUTE: Abdominal pain

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Nervous System Disturbances (HE7); Explosive, Flammable (HE18)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. OSHA does not have a PEL for 1,2-epoxybutane, but it is an OSHA select carcinogen.
  2. Vapor/air mixtures are explosive.
  3. EPA's inhalation reference concentration (daily inhalation exposure likely to be without an appreciable risk of deleterious effects during a lifetime) is 0.02 mg/m3/day.
  4. Rats exposed 6 hours/day, 4 days/week for 5 months to 2000 ppm 1,2-epoxybutane developed mild ataxia in the hindlegs and showed axonal degeneration in the dorsal portion of the fasciculus gracillis of the spinal cord. This neuropathy, however, has not been reported for human exposure to this chemical.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Butylene oxide (stabilized).
  • U.S. EPA Integrated Risk Information System: 1,2-Epoxybutane (CASRN 106-88-7).
  • No authors: 1,2-Epoxybutane [381 KB PDF, 171 pages]. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 2): 629-640, 1999.
  • Ohnishi, A. and Murai, Y.: Polyneuropathy due to ethylene oxide, propylene oxide and butylene oxide. Environ. Res. 60(2): 242-247, 1993.
  • Pohanish, R.P. (editor): 1,2-Butylene Oxide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 411-412.

Date Last Revised: 10/20/2005

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