US Dept of Labor

Occupational Safety & Health AdministrationWe Can Help

1,2-Epoxybutane

General Description

  • Synonyms: 1,2-Butene oxide; Ethyloxirane; Butylene Oxide (Stabilized); EBU
  • OSHA IMIS Code Number: E225
  • Chemical Abstracts Service (CAS) Registry Number: 106-88-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EK3675000
  • Chemical Description and Physical Properties:
    • colorless liquid with characteristic odor
    • molecular weight: 72.12
    • vapor pressure: 18.8 kPa @ 20°C
    • molecular formula: C4H8O
    • boiling point: 63.3°C
    • melting point: -130°C
    • flash point: -22°C
  • Incompatibilities: Reacts with strong oxidants causing fire hazard. Vapors mixed with air easily form explosive mixtures

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Eye, skin, respiratory tract irritation; sore throat; cough, shortness of breath, pulmonary edema; nausea; confusion, dizziness, lightheadedness, unconsciousness; blisters. Ingestion Acute: Abdominal pain
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Nervous System Disturbances (HE7); Explosive, Flammable (HE18)
  • Affected Organs: Eyes, skin, respiratory system, CNS
  • Notes:
    1. OSHA does not have a PEL for 1,2-epoxybutane, but it is an OSHA select carcinogen.
    2. Vapor/air mixtures are explosive.
    3. EPA's inhalation reference concentration (daily inhalation exposure likely to be without an appreciable risk of deleterious effects during a lifetime) is 0.02 mg/m3/day.
    4. Rats exposed 6 hours/day, 4 days/week for 5 months to 2000 ppm 1,2-epoxybutane developed mild ataxia in the hindlegs and showed axonal degeneration in the dorsal portion of the fasciculus gracillis of the spinal cord. This neuropathy, however, has not been reported for human exposure to this chemical.
  • Literature Basis:
    • International Chemical Safety Cards (WHO/IPCS/ILO): Butylene oxide (stabilized).
    • U.S. EPA Integrated Risk Information System: 1,2-Epoxybutane (CASRN 106-88-7).
    • No authors: 1,2-Epoxybutane. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 2): 629-640, 1999.
    • Ohnishi, A. and Murai, Y.: Polyneuropathy due to ethylene oxide, propylene oxide and butylene oxide. Environ. Res. 60(2): 242-247, 1993.
    • Pohanish, R.P. (editor): 1,2-Butylene Oxide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 411-412.
  • Date Last Revised: 10/20/2005

** All Trademarks are the property of their respective owners.

Search Chemical Sampling Information

Index

By Name

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

By CAS Number
collage image - OSHA Salt Lake Technical Center
Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.

Close