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Chemical Sampling Information (CSI)
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General Description

Synonyms: 3-(3,4-Dichlorophenyl)-1,1-dimethylurea; Diurex; Karmex

OSHA IMIS Code Number: 2684

Chemical Abstracts Service (CAS) Registry Number: 330-54-1

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: YS8925000

NIOSH Pocket Guide to Chemical Hazards, Diuron: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 10 mg/m3 TWA

Health Factors

Potential Symptoms: Irritation of eyes, skin, nose, throat; in animals: anemia, methemoglobinemia

Health Effects: Irritation-Eyes-Nose, Throat---Mild (HE16)

Affected Organs: Eyes, skin, respiratory system, blood

Notes:

  1. Diuron is an herbicide that inhibits photosynthesis and is considered to have low toxicity in mammals.
  2. OSHA does not have a PEL for diuron. 3. EPAs oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of diuron is 0.002 mg/kg/day.
  3. Blood and urinary metabolites identified in a human diuron overdose case included 1-(3,4-diphenyl)-3-methylurea and 1-(3,4-dichlorophenyl)urea.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Diuron.
  • U.S. EPA Integrated Risk Information System: Diuron (CASRN 330-54-1).
  • Pohanish, R.P. (editor): Diuron. In, Sittigs Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 996-998.
  • Van Boven, M., Laruelle, L. and Daenens, P.: HPLC analysis of diuron and metabolites in blood and urine. J. Anal. Toxicol. 14 (4): 231-234, 1990.

Date Last Revised: 01/20/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
    analytical solvent: Acetonitrile
    maximum volume: 60 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA PV2097)
    method classification: Patrially Validated
    note: Protect the samples from light.

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