<< Back to Chemical Sampling Information

Chemical Sampling Information (CSI)
Search (use word(s)/phrase)
Table of Contents
By Name
A B C D E F G H I J K L M
N O P Q R S T U V W X Y Z

By CAS Number
Quick Links

General Description

Synonyms: Butyrone; DPK; 4-Heptanone; Heptan-4-one; Propyl ketone

OSHA IMIS Code Number: D178

Chemical Abstracts Service (CAS) Registry Number: 123-19-3

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MJ5600000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2710 128

NIOSH Pocket Guide to Chemical Hazards, Dipropyl ketone: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 235 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 50 ppm, 235 mg/m3 TWA

Health Factors

Potential Symptoms: Irritation of eyes, skin; cough, sore throat; headache; CNS depression, dizziness, drowsiness, decreased breathing; dry skin; in animals: liver injury; narcosis; INGES. ACUTE: Nausea, vomiting, diarrhea.

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)

Affected Organs: Eyes, skin, CNS, respiratory system; liver

Notes:

  1. OSHA does not have a PEL for dipropyl ketone, and no reports of occupational exposure or biomonitoring were found in the literature.
  2. Above 49ºC, explosive vapor/air mixtures of dipropyl ketone may be formed.
  3. Dipropyl ketone (4-heptanone) is listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515), and it occurs naturally in certain foods (e.g., bread, chicken fat, coffee, baked potatoes).
  4. Although dipropyl ketone is found in human urine, its reported elevation in diabetics was not caused by diabetes, but was due to its being a metabolite of di(2-ethylhexyl)phthalate, a leachable plasticizer used in various medical devices and other vinyl materials.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Dipropyl ketone.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Dipropyl ketone.
  • Pohanish, R.P. (editor): Dipropyl Ketone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 983-985.
  • Wahl, H.G., Hong, Q., Hildenbrand, S., Risler, T., Luft, D. and Liebich, H.: 4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrol. Dial. Transplant. 19(10): 2576-2583, 2004.

Date Last Revised: 02/13/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Carbosieve S-III Tube (130/65 mg sections; 60/80 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Partially Validated

** All Trademarks are the property of their respective owners.