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Synonyms: Butyrone; DPK; 4-Heptanone; Heptan-4-one; Propyl ketone
OSHA IMIS Code Number: D178
Chemical Abstracts Service (CAS) Registry Number: 123-19-3
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MJ5600000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2710 128
NIOSH Pocket Guide to Chemical Hazards, Dipropyl ketone: chemical description, physical properties, potentially hazardous incompatibilities, and more
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 235 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 50 ppm, 235 mg/m3 TWA
Potential Symptoms: Irritation of eyes, skin; cough, sore throat; headache; CNS depression, dizziness, drowsiness, decreased breathing; dry skin; in animals: liver injury; narcosis; INGES. ACUTE: Nausea, vomiting, diarrhea.
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)
Affected Organs: Eyes, skin, CNS, respiratory system; liver
- OSHA does not have a PEL for dipropyl ketone, and no reports of occupational exposure or biomonitoring were found in the literature.
- Above 49ºC, explosive vapor/air mixtures of dipropyl ketone may be formed.
- Dipropyl ketone (4-heptanone) is listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515), and it occurs naturally in certain foods (e.g., bread, chicken fat, coffee, baked potatoes).
- Although dipropyl ketone is found in human urine, its reported elevation in diabetics was not caused by diabetes, but was due to its being a metabolite of di(2-ethylhexyl)phthalate, a leachable plasticizer used in various medical devices and other vinyl materials.
- NIOSH Pocket Guide to Chemical Hazards: Dipropyl ketone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Dipropyl ketone.
- Pohanish, R.P. (editor): Dipropyl Ketone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 983-985.
- Wahl, H.G., Hong, Q., Hildenbrand, S., Risler, T., Luft, D. and Liebich, H.: 4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrol. Dial. Transplant. 19(10): 2576-2583, 2004.
Date Last Revised: 02/13/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Carbosieve S-III Tube (130/65 mg sections; 60/80 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters
maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Salt Lake Technical Center In-House File
method classification: Partially Validated
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