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Dipropylene Glycol Methyl Ether

General Description

Synonyms: (2-Methoxymethylethoxy)propanol; bis-(2-Methoxypropyl) ether; DPGME; Dipropylene glycol monomethyl ether; Dowanol® 50B

OSHA IMIS code: 1014

CAS number: 34590-94-8

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • charcoal tube (100/50 mg sections, 20/40 mesh) 
  • maximum volume: 10 L 
  • maximum flow rate: 0.1 L/min 
  • current analytical method: gas chromatography; GC/FID 
  • analytical solvent: (95:5) methylene chloride:methanol 
  • method reference: OSHA 101 (fully validated)
Wipe Sampling Method:
  • charcoal pad
  • note: Seal in glass vial for shipment

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs

OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1

100 ppm (600 mg/m3) TWA
Skin
HE3 -- cardiac depression, liver changes
HE8 -- central nervous system depression - narcosis
HE10 -- changes in the lung
HE11 -- respiratory arrest
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
100 ppm (600 mg/m3) TWA
Skin
HE3 -- cardiac depression, liver changes
HE8 -- central nervous system depression - narcosis
HE10 -- changes in the lung
HE11 -- respiratory arrest
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards
100 ppm (600 mg/m3) TWA
Skin
HE3 -- cardiac depression, liver changes
HE8 -- central nervous system depression - narcosis
HE10 -- changes in the lung
HE11 -- respiratory arrest
NIOSH REL 100 ppm (600 mg/m3) TWA
150 ppm (900 mg/m3) STEL
Skin
HE7 -- central nervous system effects - nausea, sleepiness
HE15 -- eye and nose irritation
ACGIH TLV® (1979) 100 ppm (606 mg/m3) TWA
150 ppm (909 mg/m3) STEL
Skin
HE8 -- central nervous system impairment - narcosis
HE15 -- eye, nose, and throat irritation
CAL/OSHA PELs 100 ppm (600 mg/m3) TWA 
150 ppm (900 mg/m3) STEL
Skin
HE8 -- central nervous system impairment - narcosis
HE15 -- eye, nose, and throat irritation

Carcinogenic classification:

  • NTP: Not listed
  • IARC: Not listed
  • EPA: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: 600 ppm

Notes on other potential health effects and hazards:

  1. DPGME is combustible, and above 74°C, explosive vapor/air mixtures may form (NIOSH/IPCS 1999).
  2. A good correlation was found between inhalational exposure of floor lacquerers to DPGME and its excretion in urine during an 8-hour shift (Latinen et al. 2006).
  3. Exposure to DPGME may also occur by absorption through the skin (Venier et al. 2004).
  4. A study of eye irritation in rabbits and human volunteers indicated that DPGME also caused a transient increase in intraocular tension. A 40-µl droplet of 20% (v/v.) aqueous DPGME increased intraocular tension by 12-50%, which returned to baseline tension within an hour in most (9 of 10) volunteers (Ballantyne 1984).
  5. Used in water based cleaners.

Partial reference list:

  • ACGIH: Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - (2-Methoxymethylethoxy)Propanol. 2016.
  • Ballantyne, B.: Local ophthalmic effects of dipropylene glycol monomethyl ether. J. Toxicol. Cut. Ocular Toxicol. 2(4-5): 229-242, 1984.
  • Laitinen, J., Liesivuori, J., and Harvima, R.: Evaluation of exposure to 1-alkoxy-2-propanols and 1-(2-methoxy-1-methylethoxy)-2-propanol by the analysis of the parent compounds in urine. Toxicol. Lett. 162(2-3): 186-194, 2006.
  • NIOSH: Occupational Health Guideline for Dipropylene Glycol Methyl Ether. 1978.
  • NIOSH/CEC/IPCS: International Chemical Safety CardsDipropyleneglycol Monomethylether. October 20, 1999.
  • Venier, M., Adami, G., Larese, F., Maina, G., and Renzi, N.: Percutaneous absorption of 5 glycol ethers through human skin in vitro. Toxicol. In Vitro 18(5): 665-671, 2004.

Chemical Sampling Information

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