- Chemical Sampling Information
Synonyms: N,N-Dimethylethanamine; N,N-Dimethylethylamine; Ethyldimethylamine; N-ethyldimethylamine; Methanamine, N-ethyl-N-methyl
OSHA IMIS code: 0915
CAS number: 598-56-1
Chemical description and physical properties:
- clear liquid with a strong ammonia-like odor
- molecular formula: C4H11N
- molecular weight: 73.14
- boiling point: 37°C
- flash point: -36°C
- melting point: -140°C
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method:
- alumina tube (400/200 mg sections)
- maximum volume: 4 L
- maximum flow rate: 0.1 L/min
- current analytical method: gas chromatography; GC/NPD
- analytical solvent: deionized water (pH 7)
- method reference: OSHA PV2096 (partially validated)
Exposure Limits and Health Effects (Updated September 6, 2012)
|Standard Set By||Exposure Limit||Health Effect Codes -- Health Effects and Target Organs|
|NIOSH REL||Not established|
|ACGIH TLV®||Not established|
|CAL/OSHA PELs||Not established|
- NTP: Not listed
- IARC: Not listed
- EPA: Not listed
EPA Inhalation Reference Concentration (RfC): Not established
ATSDR Inhalation Minimal Risk Levels (MRLs): Not established
NIOSH IDLH concentration: Not established
Notes on other potential health effects and hazards:
- Visual disturbances (except blindness from direct contact of liquid with eyes) may occur at concentrations above 5 ppm TWA and are reversible within three hours after the end of exposure (Ståhlbom et al. 1991; Warren and Selchan 1988).
- Dimethylethylamine has been shown to irritate the eyes, skin, and mucous membranes and induce blurred vision, headache, nausea, faintness, chest and abdominal pain, and increased heart rate (NIOSH 1987).
- Some dimethylethylamine is excreted in the urine unchanged (mean post-shift half-life = 1.5 hours), but most is excreted as the metabolite dimethylethylamine-N-oxide (mean post-shift half-life = 2.9 hours) (Lundh et al. 1991).
- Although dimethylethylamine can be absorbed through the skin, this is not an important route for systemic exposure compared with pulmonary absorption (Lundh et al. 1997).
- Used in "cold box" coremaking with isocyanates-polyurethane systems in foundries.
- Employees may be at risk to injury at or after work because of visual disturbances (Albrecht 1999).
Partial reference list:
- Lundh, T., Boman, A., and Åkesson. B.: Skin absorption of the industrial catalyst dimethylethylamine in vitro in guinea pig and human skin, and of gaseous dimethylethylamine in human volunteers. Int. Arch. Occup. Environ. Health 70(5): 309-313, 1997.
- Lundh, T., Ståhlbom, B., and Åkesson. B.: Dimethylethylamine in mould core manufacturing: exposure, metabolism and biological monitoring. Br. J. Ind. Med.48(3): 203-207, 1991.
- NIOSH: Preventing Vision Disturbances and Acute Physical Distress Due to Dimethylethylamine (DMEA). 1987.
- Ståhlbom, B., Lundh, T., Floren, I., and Åkesson, B.: Visual disturbances in man as a result of experimental and occupational exposure to dimethylethylamine. Br. J. Ind. Med. 48(1): 26-29, 1991.
- Warren, D.W., Jr. and Selchan, D.F.: An industrial hygiene appraisal of triethylamine and dimethylethylamine exposure limits in the foundry industry. Am. Ind. Hyg. Assoc. J. 49(12): 630-634, 1988.
- Albrecht WN and Stephenson RL, Health hazards of tertiary amine catalysts: Scan J Work Env Health, 14:209-218, 1999.
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