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Chemical Sampling Information (CSI)
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General Description

Synonyms: DIBK; sym-Diisopropyl acetone; 2,6-Dimethyl-4-heptanone; Isovalerone; Valerone

OSHA IMIS Code Number: 0924

Chemical Abstracts Service (CAS) Registry Number: 108-83-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MJ5775000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1157 128

NIOSH Pocket Guide to Chemical Hazards, Diisobutyl Ketone: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table - 50 ppm, 290 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A - 50 ppm, 290 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 50 ppm, 290 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 25 ppm, 145 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 25 ppm, 150 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm

Potential Symptoms: Eye, nose, throat irritation; headache; cough, sore throat; nausea, vomiting; dizziness; dermatitis; numbness of the skin; liver, kidney damage.

Health Effects: Irritation-Eye, Nose, Throat, Skin - Mild (HE16); Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS, liver, kidneys

Notes:

  1. Above 49C, diisobutyl ketone vapor/air mixtures may be explosive.
  2. Deficits in manual motor speed, verbal fluency, visuospacial organization, and short-term memory, as well as white matter lesions in subcortical brain regions detected by MRI examination, were reported for a senior laboratory technician occupationally exposed to unknown concentrations of vapors of diisobutyl ketone, which was heated under pressure.
  3. The concentration of diisobutyl ketone causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 287 ppm.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Diisobutyl Ketone.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Diisobutyl ketone.
  • De Ceaurriz, J., Micillino, J.C., Marignac, B., Bonnet, P., Muller, J. and Guenier, J.P.: Quantitative evaluation of sensory irritating and neurobehavioral properties of aliphatic ketones in mice. Food Chem. Toxicol. 22 (7): 545-549, 1984.
  • Pohanish, R.P. (editor): Diisobutyl Ketone. In, Sittigs Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 895-896.
  • White, R.F., Feldman, R.G., Moss, M.B. and Proctor, S.P.: Magnetic resonance imaging (MRI), neurobehavioral testing, and toxic encephalopathy: two cases. Environ. Res.61 (1): 117-123, 1993.

Date Last Revised: 06/14/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min.
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1300 [27 KB PDF, 5 pages])
    method classification: Fully Validated

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