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Synonyms: 1,2-Benzenedicarboxylic acid diethyl ester; DEP; Diethyl ester of phthalic acid; Ethyl phthalate; Phthalic acid, diethyl ester
OSHA IMIS Code Number: 0933
Chemical Abstracts Service (CAS) Registry Number: 84-66-2
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TI1050000
NIOSH Pocket Guide to Chemical Hazards, Diethyl phthalate: chemical description, physical properties, potentially hazardous incompatibilities, and more
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA
Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity
Potential Symptoms: Irritation of eyes, skin, nose, throat; headache, dizziness, nausea; lacrimation; possible polyneuropathy, vestibular dysfunction; pain, numbness, lassitude, spasms in arms and legs; in animals: reproductive effects; INGES. ACUTE: Abdominal pain, nausea.
Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16)
Affected Organs: Eyes, skin, respiratory system, CNS, peripheral nervous system, reproductive system
- OSHA does not have a PEL for diethyl phthalate.
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious non-cancer effects during a lifetime) of diethyl phthalate is 0.8 mg/kg/day.
- Diethyl phthalate is regulated as a denaturant for alcohol (27 CFR 21.106) and it is often used at a concentration of 0.5% to denature ethanol used in cosmetic products.
- Although several cases of allergy to diethyl phthalate have been reported, attempts to sensitize skin in studies with animals and human volunteers have not been successful.
- In a randomly selected adult reference U.S. population, the urinary metabolite monoethyl phthalate (median, 305 µg/L) occurred in much greater concentrations than the metabolites of six other phthalate derivatives.
- The absorption rate of diethyl phthalate was reported to be much slower through human skin than through rat skin in vitro.
- NIOSH Pocket Guide to Chemical Hazards: Diethyl phthalate.
- International Chemical Safety Cards (WHO/IPCS/ILO): Diethyl phthalate.
- U.S. EPA Integrated Risk Information System: Diethyl phthalate (CASRN 84-66-2).
- Api, A.M.: Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food Chem. Toxicol. 39(2): 97-108, 2001.
- Blount, B.C., et al.: Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 108(10): 979-982, 2000.
- David, R.M., Lockhart, L.K. and Ruble, K.L.: Lack of sensitization for trimellitate, phthalate, terephthlate and isobutyrate plasticizers in a human repeated insult patch test. Food Chem. Toxicol. 41(4): 589-593, 2003.
- Pohanish, R.P. (editor): Diethyl Phthalate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 880-882.
- Scott, R.C., Dugard, P.H., Ramsey, J.D. and Rhodes, C.: In vitro absorption of some o-phthalate diesters through human and rat skin. Environ. Health Perspect. 74: 223-227, 1987.
Date Last Revised: 05/14/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: OSHA Versatile Sampler (OVS-Tenax) - 13 mm Tenax Tube (140/70 mg sections) with a Glass Fiber filter enclosed
analytical solvent: Toluene
maximum volume: 240 Liters
maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 104)
method classification: Fully Validated
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