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Chemical Sampling Information (CSI)
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General Description

Synonyms: Carbitol; Carbitol Cellosolve; DEGEE; Poly-Solv; Solvosol; 2-(2-Ethoxyethoxy)-Ethanol

OSHA IMIS Code Number: D615

Chemical Abstracts Service (CAS) Registry Number: 111-90-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KK8750000

Chemical Description and Physical Properties:

clear liquid with a mildly sweet odor
molecular weight: 134.17
vapor pressure: 19 Pa @ 25°C
molecular formula: C6H14O3
boiling point: 197°C
melting point: -76°C

Health Factors

Potential Symptoms: Eye, skin irritation; high systemic doses in animals caused CNS depression (ataxia, lethargy, coma), pulmonary edema, anemia, enlarged livers and kidney damage

Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11)

Affected Organs: Kidneys, respiratory system, eyes, skin, CNS

Notes:

  1. OSHA does not have a PEL for diethylene glycol monoethyl ether (DEGEE).
  2. The major urinary metabolite of DEGEE in humans is 2-(2-ethoxyethoxy) acetic acid.
  3. Repeated-dose inhalational studies of DEGEE in rats indicated a NOAEL of 0.09 mg/liter for irritation of the upper respiratory tract and 1.1 mg/liter for systemic effects.
  4. Three cases of severe kidney damage and coma led the French Health Products Sanitary Safety Agency to withdraw an OTC diuretic drug (Pilosuryl) from the market in June 2003, having attributed the toxicity to the excipient, DEGEE.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Diethylene glycol monoethyl ether.
  • NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KK8750000: Ethanol, 2-(2-ethoxyethoxy)-.
  • Gaunt, I.F., Colley, J., Grasso, P., Lansdown, A.B.G. and Gangolli, S.D.: Short-term toxicity of diethylene glycol monoethyl ether in the rat, mouse and pig. Food Cosmet. Toxicol. 6(6): 689-705, 1968.
  • Hardy, C.J., Coombs, D.W., Lewis, D.J. and Klimisch, H.J.: Twenty-eight-day repeated-dose inhalation exposure of rats to diethylene glycol monoethyl ether. Fundam. Appl. Toxicol. 38(2): 143-147, 1997.
  • Miller, R.R.: Metabolism and disposition of glycol ethers. Drug. Metab. Rev. 18(1): 1-22, 1987.

Date Last Revised: 03/29/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol (v/v)
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2013)
    method classification: Partially Validated

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