- Synonyms: 2,2-Dichlorovinyl Dimethyl Phosphate; Vapona; 2,2-Dichlorobinyldimethyl Phosphate; 2,2-dichlorovinyl dimethyl ester phosphoric acid
- OSHA IMIS Code Number: 0850
- IMIS Name History: DDVP prior to 9/1/89
- Chemical Abstracts Service (CAS) Registry Number: 62-73-7
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TC0350000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2783 152
- NIOSH Pocket Guide to Chemical Hazards, Dichlorvos: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (1998): 0.1 mg/m3 (inhalable fraction and vapor) TWA; Skin; dermal sensitzer (DSEN); A4
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; Skin
- Carcinogenic Classification:
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 100 mg/m3
- Potential Symptoms: Miosis, aching eyes; rhinorrhea; headache; tight chest, wheezing, laryngeal spasms; salivation; slurred speech; cyanosis; anorexia, nausea, vomiting, abdominal cramps, diarrhea; involuntary defecation and urination; sweating, muscle fasciculation, paralysis, giddiness, ataxia; convulsions, low blood pressure; cardiac irregularities; skin, eye irritation; skin sensitization, dermatitis.
- Health Effects: Cholinesterase inhibition (HE6); LD50 (oral, rat) 56-80 mg/kg
- Affected Organs: Respiratory system, cardiovascular system, CNS, eyes, skin, blood cholinesterase
- Although no cases of neuropathy from occupational exposure have been reported, cases of a delayed neuropathy following recovery from acute poisoning with dichlorvos have been reported.
- Exposure is monitored by the measurement of plasma cholinesterase activity (recovers exponentially with a half-life around 12 days) and erythrocyte acetylcholinesterase activity (recovers linearly in about 80 days).
- One case of persistent asthma (bronchial obstruction) following occupational exposure to dichlorvos has been reported, and in another case, asthma was provoked by exposure to a cat's plastic collar containing dichlorvos.
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Dichlorvos.
- International Chemical Safety Cards (WHO/IPCS/ILO): Dichlorvos.
- EPA Air Toxics Website: Dichlorvos. U.S. Environmental Protection Agency Technology Transfer Network, Feb. 13, 2003.
- Bryant, D.H.: Asthma due to insecticide sensitivity. Aust. N.Z. J. Med. 15(1): 66-68, 1985.
- Deschamps, D., Questel, F., Baud, F.J., Gervais, P. and Dally, S.: Persistent asthma after acute inhalation of organophosphate insecticide. Lancet 344(8938): 1712, 1994.
- Mason, H.J.: The recovery of plasma cholinesterase and erythrocyte acetylcholinesterase activity in workers after over-exposure to dichlorvos. Occup. Med. (Lond.) 50(5): 343-347, 2000.
- Pohanish, R.P. (editor): Dichlorvos. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 844-846.
- Sevim, S., Aktekin, M., Dogu, O., Ozturk, H. and Ertas, M.: Late onset polyneuropathy due to organophosphate (DDVP) intoxication. Can. J. Neurol. Sci. 30(1): 75-78, 2003.
- Vasconcellos, L.F. Leite, A.C. and Nascimento, O.J.: Organophosphate-induced delayed neuropathy: case report. Arq. Neuropsiquiatr. 60(4): 1003-1007, 2002.
- Date Last Revised: 05/26/2004
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
- OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
- analytical solvent: Toluene
- maximum volume: 480 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: Gas Chromatography; GC/FPD
- method reference: OSHA Analytical Method (OSHA 62)
- method classification: Fully Validated
- note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center.
Wipe Sampling Method:
- Glass Fiber Filter
Bulk Sampling Method:
- Limit the amount of bulk submitted to one gram or one mL.
** All Trademarks are the property of their respective owners.